IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

Stable Identifier
R-HSA-8987042
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
TYK1 and JAK1 are phosphorylated by IL22:IL22RA1:JAK1:IL10RB:TYK2 receptor complex
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Inferred from rat, mouse, human :Tyrosine protein kinase JAK1 (JAK1) and Non-receptor tyrosine-protein kinase TYK2 (TYK2) are believed to be phosphorylated after Interleukin-22 interacts with its receptor. The receptor is a complex formed by Interleukin-22 receptor subunit alpha-1 (IL22RA1), JAK1, Interleukin-10 receptor subunit beta (IL10RB) and TYK2 (Lejeune et al. 2002, Sabat et al. 2014). This is a black-box event because the JAK1/TYK2 coordinates phosphorylated after IL22 stimulus are unknown.

Literature References
PubMed ID Title Journal Year
12087100 Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10

Lejeune, D, Dumoutier, L, Constantinescu, S, Kruijer, W, Schuringa, JJ, Renauld, JC

J. Biol. Chem. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created