JAK1 binds IL20RA

Stable Identifier
R-HSA-8987039
Type
Reaction [uncertain]
Species
Homo sapiens
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Tyrosine protein kinase JAK1 (JAK1) binds Interleukin-20 receptor subunit alpha (IL20RA). JAK1 coimmunoprecipitates with several class II receptor complexes including Interferon gamma receptor 1 (IFNGR1), Interferon alpha/beta receptor 2 (IFNAR2), Interferon lambda receptor 1 (IFNLR1), Interleukin-10 receptor subunit alpha (IL10RA), Interleukin-22 receptor subunit alpha 1 (IL22RA1) and Interleukin-20 receptor subunit alpha (IL20RA), leading to the suggestion that Class II receptors may have a common sequence motif for JAK recognition (Ferrao et al. 2016). This is a black box event because JAK1 binding to IL20RA is inferred from binding to related receptors and subsequent JAK/STAT signaling events (Ferrao et al 2016, Hann et al. 2006, Murakami et al. 1991).

Literature References
PubMed ID Title Journal Year
16750817 Jaks and cytokine receptors--an intimate relationship

Haan, C, Kreis, S, Margue, C, Behrmann, I

Biochem. Pharmacol. 2006
27133025 The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

Ferrao, R, Wallweber, HJ, Ho, H, Tam, C, Franke, Y, Quinn, J, Lupardus, PJ

Structure 2016
1662392 Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family

Murakami, M, Narazaki, M, Hibi, M, Yawata, H, Yasukawa, K, Hamaguchi, M, Taga, T, Kishimoto, T

Proc Natl Acad Sci U S A 1991
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