Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ATP-binding cassette sub-family E member 1 (ABCE1, aka RNase L inhibitor, RLI) is a member of the ATP-binding cassette transporters which express in the cytoplasm and the nuclear membrane. ABCE1 is induced during viral infections (Bisbal C et al. 1995; Martinand C et al. 1998, 1999). ABCE1 (RLI) was shown to associate with RNase L inhibiting the endoribonuclease activity of RNase L, thus antagonising the anti-viral effect of the IFN-regulated 2'-5' oligoadenylate/RNase L pathway (Bisbal C et al. 1995; Martinand C et al. 1998, 1999). Furthermore, overexpression or knockdown of ABCE1 (RLI) has inhibitory or promoting effects on the binding of RNase L to 2'-5' oligoadenylates, rRNA cleavage, destabilization of mitochondrial mRNA, antiviral activity, and antitumor activity (Martinand C et al. 1998, 1999; Le Roy F et al. 2001; Malathi K et al. 2004; Huang B et al. 2014; Tian Y et al. 2016). Aside from its role as an RNase-L inhibitor, ABCE1 is believed to be involved in translation termination and ribosome recycling (Dong J et al. 2004; Chen ZQ et al. 2006; Khoshnevis S et al. 2010).

Literature References
PubMed ID Title Journal Year
7539425 Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway

Bisbal, C, Martinand, C, Silhol, M, Lebleu, B, Salehzada, T

J. Biol. Chem. 1995
11265282 The 2-5A/RNase L pathway and inhibition by RNase L inhibitor (RLI)

Bisbal, C, Salehzada, T, Silhol, M, Martinand, C, Le Roy, F, Lebleu, B

Methods Mol. Biol. 2001
9847332 RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells

Martinand, C, Montavon, C, Salehzada, T, Silhol, M, Lebleu, B, Bisbal, C

J. Virol. 1999
Participant Of
Orthologous Events