OAS2 produces oligoadenylates

Stable Identifier
R-HSA-8985104
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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OAS2 produces oligoadenylates
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2'-5'-oligoadenylate synthetase 2 (OAS2) polymerizes ATP into 5'-triphosphorylated, 2'-5'-linked oligoadenylate (2-5A) (Hovanessian AG et al. 1988; Sarkar SN et al. 1999, 2002). 2-5A molecules are recognized by ribonuclease L (RNase L) (Han Y et al. 2014; Huang H et al. 2014). Activated RNase L cleaves viral and cellular RNA resulting in the inhibition of viral replication (Silverman RH 2007).
Literature References
PubMed ID Title Journal Year
10464285 The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases

Sarkar, SN, Wang, HW, Sung, SS, Sen, GC, Ghosh, A

J. Biol. Chem. 1999
3350819 Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells

Robert, N, Hovanessian, AG, Marié, I, Laurent, AG, Svab, J, Chamaret, S

J. Biol. Chem. 1988
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Catalyst Activity

2'-5'-oligoadenylate synthetase activity of OAS2:OAS2 ligand dimer [cytosol]

Physical Entity
OAS2:OAS2 ligand dimer [cytosol] (Homo sapiens)
Activity
2'-5'-oligoadenylate synthetase activity (GO:0001730)
Authored
Shamovsky, V  (2017-03-27)
Reviewed
D'Eustachio, P  (2017-12-02)
Silverman, RH  (2018-07-31)
Created
Shamovsky, V  (2017-04-12)
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