OAS2 produces oligoadenylates

Stable Identifier
R-HSA-8985104
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Respiratory syncytial virus
Compartment
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2'-5'-oligoadenylate synthetase 2 (OAS2) polymerizes ATP into 5'-triphosphorylated, 2'-5'-linked oligoadenylate (2-5A) (Hovanessian AG et al. 1988; Sarkar SN et al. 1999, 2002). 2-5A molecules are recognized by ribonuclease L (RNase L) (Han Y et al. 2014; Huang H et al. 2014). Activated RNase L cleaves viral and cellular RNA resulting in the inhibition of viral replication (Silverman RH 2007).

Literature References
PubMed ID Title Journal Year
3350819 Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells

Hovanessian, AG, Svab, J, MariƩ, I, Robert, N, Chamaret, S, Laurent, AG

J. Biol. Chem. 1988
10464285 The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases

Sarkar, SN, Ghosh, A, Wang, HW, Sung, SS, Sen, GC

J. Biol. Chem. 1999
Participants
Input
Participant Of
Catalyst Activity
Catalyst Activity
Title
2'-5'-oligoadenylate synthetase activity of OAS2:OAS2 ligand dimer [cytosol]
Physical Entity
Activity
Authored
Reviewed
Created