OAS3 produces oligoadenylates

Stable Identifier
R-HSA-8985091
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Sindbis virus, Influenza A virus, Dengue virus, West Nile virus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

2'-5'-oligoadenylate synthetase 3 (OAS3) is a template-independent nucleotidyl transferase that, once activated by double-stranded RNA in the cytosol, produces second messenger molecules 5'-triphosphorylated 2′,5′-linked oligoadenylates (2-5A). OAS3 was reported to produce preferentially dimeric 2-5A (Rebouillat D et al. 1999). However recent reports showed that OAS3 is able to synthesize 2',5'-oligoadenylates of sufficient length (the triadenylate and longer) to activate RNase L and thus limit viral propagation (Ibsen MS et al. 2014; Li Y et al. 2016).

Literature References
PubMed ID Title Journal Year
26858407 Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses

Li, Y, Banerjee, S, Wang, Y, Goldstein, SA, Dong, B, Gaughan, C, Silverman, RH, Weiss, SR

Proc. Natl. Acad. Sci. U.S.A. 2016
25275129 The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation

Ibsen, MS, Gad, HH, Thavachelvam, K, Boesen, T, Desprès, P, Hartmann, R

J. Virol. 2014
Participants
Input
Participant Of
Catalyst Activity
Catalyst Activity
Title
2'-5'-oligoadenylate synthetase activity of OAS3:OAS3 ligand [cytosol]
Physical Entity
Activity
Authored
Reviewed
Created