Reactome | p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor

p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor

Stable Identifier

R-HSA-8983983

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor

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Signal transducer and activator of transcription 1-alpha/beta(STAT1) and Signal transducer and activator of transcription 4 (STAT4) after phosphorylation dissociates from the complex of ligand receptor and will dimerize (Delgoffe & Vignali 2013). This is a Black Box event because the mechanism of the release of STAT1 and STAT4 from the receptor complex is unclear. However, it is reported that simultaneous activation of IL12RB2 or IL6ST homodimer receptors do not promote the formation of pSTAT1:pSTAT4 and only the activation of the IL12RB2:IL6ST heteromeric receptor favours pSTAT1:pSTAT4 formation. For this reason, STAT1 and STAT4 are simultaneously considered in the binding, activation and release events.

Literature References

PubMed ID	Title	Journal	Year
22306691	The composition and signaling of the IL-35 receptor are unconventional Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM	Nat. Immunol.	2012