Reactome | p-STAT1 dissociates from IL6ST:IL6ST

p-STAT1 dissociates from IL6ST:IL6ST

Stable Identifier

R-HSA-8983845

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

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Interleukin-35 (IL35) can signal via IL35 receptors triggering the JAK/STAT pathway downstream. Signal transducer and activator of transcription 1-alpha/beta (STAT1) binds to the JAK associated-IL35 receptor complex and is activated via phosphorylations. Subsequently, phosphorylated p-STAT1 dissociates from the receptor complex (Collison et al. 2012). This is a black box event because there is no literature evidence about the exact mechanism of the release of STAT1 from the receptor complex.

Literature References

PubMed ID	Title	Journal	Year
22306691	The composition and signaling of the IL-35 receptor are unconventional Collison, LW, Delgoffe, GM, Guy, CS, Vignali, KM, Chaturvedi, V, Fairweather, D, Satoskar, AR, Garcia, KC, Hunter, CA, Drake, CG, Murray, PJ, Vignali, DA	Nat. Immunol.	2012