STAT1 associates with IL6ST:IL6ST

Stable Identifier
R-HSA-8983841
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Interleukin-35 (IL35) binding activates the IL35 receptor complex and facilitates JAKs phosphorylation. Subsequently, Signal transducer and activator of transcription 1-alpha/beta (STAT1) binds to the receptor complex and is activated by tyrosine phosphorylation (Collison et al. 2012). This is a black box event because the receptor subunit responsible for STAT1 binding to the receptor is unclear.

Literature References
PubMed ID Title Journal Year
22306691 The composition and signaling of the IL-35 receptor are unconventional

Collison, LW, Delgoffe, GM, Guy, CS, Vignali, KM, Chaturvedi, V, Fairweather, D, Satoskar, AR, Garcia, KC, Hunter, CA, Drake, CG, Murray, PJ, Vignali, DA

Nat. Immunol. 2012
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created