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IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2
Stable Identifier
R-HSA-8983425
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
Synonyms
GAB2 binds GRB2 from the IL15RA:IL15:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 complex
ReviewStatus
5/5
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)
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Inferred from mouse: GRB2 associated binding protein 2 (GAB2) is believed to bind and be phosphorylated in response to Interleukin-2 (IL2) and Interleukin-15 (IL15) stimulation. Its phosphorylation is greatly diminished by mutation of the site in the Interleukin-2 Receptor beta chain (Y338F) (IL2RB, IL2Rβ) that recruits SHC transforming protein 1 (SHC1) (Gadina et al.2000, Wöhrle et al.2009, Gesbert et al. 1998, Brockdorff et al. 2001). GAB2 is a phosphoprotein that is suggested to associates with PI3kinase, Growth factor receptor-bound protein 2 (GRB2) and Tyrosine protein phosphatase non-receptor type 11 (PTPN11 or SHP2) in T and Natural Killer (NK) cells (Gu et al. 2000).This is a black box event because GAB2 binding is inferred from IL15 stimulation of GAB2 phosphorylation (Brockdorff et al. 2001). More in detail, human and mouse IL15 have 70.2% amino acid sequence similarity and exhibit similar trans-presentation mechanism, signal transduction machinery and biological activities. Similarly, human IL15 shows cross-reactivity with mouse cells and it was demonstrated that human and mouse IL15 showed similar responses in mouse models (Stoklasek et al. 2006) (Patidar et al. data not published).
Participants
Input
GAB2 [cytosol]
(Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane]
(Homo sapiens)
Output
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Interleukin-15 signaling (Homo sapiens)
Inferred From
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2 (Mus musculus)
Authored
Duenas, C (2017-08-07)
Reviewed
Patidar, M (2017-08-07)
Created
Duenas, C (2017-03-23)
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