Reactome | p-Y-STAT3 binds p-STAT5

p-Y-STAT3 binds p-STAT5

Stable Identifier

R-HSA-8983373

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Signal transducer and activator of transcription 3 (STAT3) is believed to bind Signal transducer and activator of transcription 5A/5B (STAT5). IL15 stimulation leads to the formation of DNA binding complexes that contain STAT3 and STAT5 (Johnston et al. 1995, Giron-Michel et al. 2003). This is a black box event because dimer formation is inferred from STAT3 and STAT5 co-occurrence in DNA binding complexes.

Literature References

PubMed ID	Title	Journal	Year
12623850	Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules van Dijk, M, Clay, D, Fogli, M, Chouaib, S, Bompais, H, Lebousse-Kerdilès, C, Briard, D, Ferrini, S, Azzarone, B, Meazza, R, Péault, B, Caignard, A, Brouty-Boyé, D, Giron-Michel, J	Blood	2003
7568001	Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15 Ortaldo, JR, Finbloom, DS, Shibuya, K, Kaplan, D, Giri, JD, Bacon, CM, Chen, YQ, Gupta, S, Johnston, JA, Rees, RC	Proc Natl Acad Sci U S A	1995