Reactome | GRB2 [cytosol]

GRB2 [cytosol]

Stable Identifier

R-HSA-8983328

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Icon

Locations in the PathwayBrowser for interactor UniProt:Q92734 TFG

Expand all

External Reference Information

External Reference

UniProt:P62993 GRB2

Gene Names

GRB2, ASH

Chain

chain:1-217

Reference Genes

BioGPS Gene:2885 GRB2

COSMIC (genes):GRB2 GRB2

CTD Gene:2885 GRB2

dbSNP Gene:2885 GRB2

ENSEMBL:ENSG00000177885 GRB2

HGNC:4566 GRB2

KEGG Gene (Homo sapiens):2885 GRB2

Monarch:2885 GRB2

NCBI Gene:2885 GRB2

OMIM:108355 GRB2

UCSC:P62993 GRB2

Reference Transcript

Other Identifiers

0007050215

11718334_a_at

11741435_s_at

1565_s_at

16848807

1AZE

1BM2

1BMB

1CJ1

1FHS

1FYR

1GCQ

1GFC

1GFD

1GHU

1GRI

1IO6

1JYQ

1JYR

1JYU

1QG1

1TZE

1X0N

1ZFP

215075_s_at

223049_at

2589

2885

2AOA

2AOB

2H46

2H5K

2HUW

2VVK

2VWF

2W0Z

30749

30750

33855_at

3770746

3770747

3770748

3770749

3770750

3770751

3770752

3770753

3770754

3770755

3770756

3770757

3770758

3770761

3770772

3770773

3770774

3770777

3770778

3C7I

3IMD

3IMJ

3IN7

3IN8

3KFJ

3MXC

3MXY

3N7Y

3N84

3N8M

3OV1

3OVE

3S8L

3S8N

3S8O

3WA4

46217_at

4P9V

4P9Z

5CDW

8018364

A_23_P77847

A_24_P39654

A_24_P407717

AAA58448

AAC37549

AAC72075

AAH00631

AAM21073

ABY87532

AC011933

AF063614

AF063615

AF063616

AF063617

AF063618

AF498925

AGC09591

AK315565

B0LPF3

BAG37940

BC000631

CAA44664

CAB002589

CAG46740

CCDS11721

CCDS11722

CH471099

CR541942

EAW89270

ENSG00000177885

ENSP00000317360

ENSP00000339007

ENSP00000376345

ENSP00000376346

ENSP00000376347

ENSP00000496913

ENST00000316615

ENST00000316615.9

ENST00000316804

ENST00000316804.9

ENST00000392562

ENST00000392562.5

ENST00000392563

ENST00000392563.5

ENST00000392564

ENST00000392564.5

ENST00000648046

ENST00000648046.1

EntrezGene:2885

EntrezGene:GRB2

EU332843

g12005510_3p_at

GE78983

GE83126

GO:0000003

GO:0000165

GO:0000902

GO:0001784

GO:0002376

GO:0003674

GO:0003723

GO:0005070

GO:0005154

GO:0005168

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005768

GO:0005794

GO:0005829

GO:0005886

GO:0005911

GO:0006464

GO:0006810

GO:0006950

GO:0007010

GO:0007155

GO:0007165

GO:0007173

GO:0007265

GO:0007267

GO:0007411

GO:0007568

GO:0008150

GO:0008180

GO:0008286

GO:0008543

GO:0009790

GO:0009967

GO:0012506

GO:0016020

GO:0016032

GO:0016192

GO:0017124

GO:0019221

GO:0019899

GO:0019901

GO:0019903

GO:0019904

GO:0022607

GO:0030154

GO:0030674

GO:0030838

GO:0031295

GO:0031410

GO:0031623

GO:0032991

GO:0035635

GO:0035723

GO:0038095

GO:0038096

GO:0038128

GO:0040011

GO:0042059

GO:0042770

GO:0042802

GO:0043226

GO:0043408

GO:0043560

GO:0044403

GO:0046579

GO:0046875

GO:0048011

GO:0048646

GO:0048856

GO:0048870

GO:0050900

GO:0051219

GO:0051291

GO:0051897

GO:0060670

GO:0061024

GO:0065003

GO:0070062

GO:0070436

GO:0071479

GO:2000379

GRB2

GRB2-201

GRB2-202

GRB2-203

GRB2-204

GRB2-205

GRB2-212

HGNC:4566

HPA030749

HPA030750

Hs.296381.1.A1_3p_a_at

ILMN_1742521

ILMN_1748797

IPR000980

IPR001452

IPR030219

IPR035641

IPR035643

IPR036028

IPR036860

J3KT38

J3QRL5

JX512444

L29511

M96995

M96995_s_at

MIM:108355

NM_002086

NM_203506

NP_002077

NP_987102

PF00017

PF00018

PH_hs_0024870

PR00401

PR00452

PR00499

SM00252

SM00326

TC17001877.hg

UPI000002AABD

UPI000004EF93

X62852

Participant Of

input

IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2

hasComponent

IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane]

Inferred To

GRB2-1 [cytosol] (Bos taurus)

GRB2-1 [cytosol] (Canis familiaris)

GRB2-1 [cytosol] (Danio rerio)

GRB2-1 [cytosol] (Gallus gallus)

GRB2-1 [cytosol] (Mus musculus)

GRB2-1 [cytosol] (Rattus norvegicus)

GRB2-1 [cytosol] (Sus scrofa)

GRB2-1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_987102.1, NP_002077.1

OpenTargets

ENSG00000177885

ZINC - Substances

GRB2_HUMAN

GeneCards

P62993

ZINC target

P62993

PRO

P62993

ZINC - Predictions - Purchasable

GRB2_HUMAN

HMDB Protein

HMDBP11487

PDB

1BM2, 3N8M, 2VWF, 5CDW, 1GHU, 1CJ1, 3IN8, 2VVK, 1FHS, 2HUW, 3S8N, 1JYQ, 1GRI, 3MXY, 4P9V, 1GCQ, 1ZFP, 1TZE, 3KFJ, 1JYR, 2AOB, 3IN7, 3N7Y, 2H46, 3WA4, 2H5K, 3C7I, 3S8O, 1BMB, 1QG1, 1JYU, 1IO6, 3IMD, 1AZE, 1FYR, 2W0Z, 1X0N, 3MXC, 1GFC, 3OV1, 3IMJ, 4P9Z, 2AOA, 3S8L, 3N84, 1GFD, 3OVE

Interactors (200)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.978	47
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.968	26
UniProt:Q07889 SOS1	3	SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [cytosol] (R-HSA-64847)	0.967	24
UniProt:P22681 CBL	6	p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [cytosol] (R-HSA-182940) CBL [cytosol] (R-HSA-112199) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)	0.958	16
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.954	23
UniProt:Q9UQC2 GAB2	4	p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) p-5Y-GAB2 [cytosol] (R-HSA-8855574) GAB2 [cytosol] (R-HSA-508239) p-Y-GAB2 [cytosol] (R-HSA-912529)	0.935	11
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.926	9
UniProt:P11274 BCR	4	BCR-FGFR1 fusion [cytosol] (R-HSA-1604524) BCR [cytosol] (R-HSA-195200) pY177-BCR-p-FGFR1 fusion [cytosol] (R-HSA-1839041) BCR-p-FGFR1 fusion [cytosol] (R-HSA-1838979)	0.921	11
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.912	11
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.912	14
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.899	9
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.888	8
UniProt:Q9UJM3 ERRFI			0.888	13
UniProt:P50570 DNM2	5	DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [plasma membrane] (R-HSA-2984201) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [Golgi membrane] (R-HSA-2980842)	0.886	7
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) KHDRBS1 [nucleoplasm] (R-HSA-8848941) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995)	0.868	8
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.863	6
UniProt:Q9H706 GARE1			0.861	8
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.857	8
UniProt:P04626 ERBB2	12	p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.831	5
UniProt:Q9UKW4 VAV3	2	p-Y173-VAV3 [cytosol] (R-HSA-442287) VAV3 [cytosol] (R-HSA-430152)	0.83	7
UniProt:Q13480 GAB1	4	p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306) p-5Y-GAB1 [cytosol] (R-HSA-180344) GAB1 [cytosol] (R-HSA-179795)	0.822	9
UniProt:Q9Y4K4 M4K5			0.818	5
UniProt:P35235 Ptpn11	5	Ptpn11 [cytosol] (R-MMU-210002) p-Y546,Y584-Shp2 [cytosol] (R-MMU-443116) PTPN11 [nucleoplasm] (R-MMU-8937745) PTPN11 [cytosol] (R-MMU-162563) phospho-p-Y546,Y584-PTPN11 [cytosol] (R-MMU-162573)	0.809	7
UniProt:P61978 HNRNPK	2	SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.801	9
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.786	7
UniProt:Q9UKT9 IKZF3			0.781	7
UniProt:Q05193 DNM1	3	DNM1 [cytosol] (R-HSA-2213182) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [plasma membrane] (R-HSA-177488)	0.779	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.75	5
UniProt:O43516 WIPF1	1	WIPF1 [cytosol] (R-HSA-201874)	0.745	4
UniProt:Q8TF74 WIPF2	1	WIPF2 [cytosol] (R-HSA-2197666)	0.745	4
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.744	6
UniProt:Q8WV28 BLNK	2	p-5Y-BLNK [plasma membrane] (R-HSA-983579) BLNK [cytosol] (R-HSA-912750)	0.743	5
UniProt:P10721 KIT	4	p-S741,S746-KIT [plasma membrane] (R-HSA-1433492) p-8Y-KIT [plasma membrane] (R-HSA-1472116) KIT [plasma membrane] (R-HSA-197662) p-7Y-KIT [plasma membrane] (R-HSA-205207)	0.743	6
UniProt:P35570 Irs1	7	p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-1168867) phospho-p-6Y-IRS1 [plasma membrane] (R-RNO-2445090) IRS1 [plasma membrane] (R-RNO-2425392) IRS1 [cytosol] (R-RNO-74769) phospho-p-Y-IRS1 [cytosol] (R-RNO-74772) phospho-p-Y-IRS1 [plasma membrane] (R-RNO-198366)	0.737	5
UniProt:Q8N1K5 THMS1			0.737	10
UniProt:Q92918 M4K1			0.72	8
UniProt:O43561 LAT	3	LAT [plasma membrane] (R-HSA-202322) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829) p-5Y-LAT [plasma membrane] (R-HSA-202364)	0.708	7
UniProt:Q62245 Sos1	4	Sos1 [cytosol] (R-MMU-443318) phospho-p-4S-SOS1 [cytosol] (R-MMU-109821) SOS1 [plasma membrane] (R-MMU-983559) SOS1 [cytosol] (R-MMU-64847)	0.704	4
UniProt:B7ZLH0 B7ZLH0			0.696	5
UniProt:P15498 VAV1	5	p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087) VAV1 [cytosol] (R-HSA-195066) p-Y174-VAV1 [cytosol] (R-HSA-437946) VAV1 [plasma membrane] (R-HSA-1045153)	0.692	3
UniProt:Q08209 PPP3CA	2	PPP3CA [cytosol] (R-HSA-201771) PPP3CA [nucleoplasm] (R-HSA-2685599)	0.678	3
UniProt:P21860 ERBB3			0.678	5
UniProt:Q14185 DOCK1	1	DOCK1 [cytosol] (R-HSA-372654)	0.678	3
UniProt:O43150 ASAP2			0.678	3
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.676	3
UniProt:Q16643 DREB			0.674	4
UniProt:P11137 MTAP2			0.674	7
UniProt:O60636 TSN2			0.672	6
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.669	3
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.666	4
UniProt:P98078	3	DAB2 [lysosomal membrane] (R-MMU-2980807) DAB2 [cytosol] (R-MMU-8862456) DAB2 [plasma membrane] (R-MMU-2980808)	0.662	4
UniProt:P35579 MYH9	1	MYH9 [cytosol] (R-HSA-419173)	0.659	3
UniProt:O00459 PIK3R2	2	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554)	0.659	4
UniProt:Q6ZUJ8 PIK3AP1	1	p-4Y-PIK3AP1 [plasma membrane] (R-HSA-984814)	0.659	3
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.659	3
UniProt:Q07912 ACK1			0.658	4
UniProt:Q13905 RAPGEF1	3	RAPGEF1 [cytosol] (R-HSA-913472) RAPGEF1 [cytosol] (R-HSA-3008672) RAPGEF1 [endosome] (R-HSA-3008667)	0.658	3
UniProt:P27958 Genome polyprotein	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.656	3
UniProt:P21802 FGFR2	35	FGFR2 [plasma membrane] (R-HSA-2023840) FGFR2 IIIa TM [extracellular region] (R-HSA-8851703) FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853137) FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane] (R-HSA-8853154) FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853123) FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane] (R-HSA-8853158) FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane] (R-HSA-8853150) FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane] (R-HSA-8853153) FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane] (R-HSA-8853139) FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane] (R-HSA-8853159) FGFR2 N549H [plasma membrane] (R-HSA-2033296) FGFR2 N549K [plasma membrane] (R-HSA-1637910) FGFR2 K660N [plasma membrane] (R-HSA-1637905) FGFR2 K660M [plasma membrane] (R-HSA-1637902) FGFR2 K660E [plasma membrane] (R-HSA-1637900) FGFR2 S267P [plasma membrane] (R-HSA-1637920) FGFR2 L764fs4 [plasma membrane] (R-HSA-1637908) FGFR2 W290C [plasma membrane] (R-HSA-1637929) p-6Y FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853134) p-6Y FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853146) p-6Y FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane] (R-HSA-8853132) p-6Y FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane] (R-HSA-8853121) p-6Y FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane] (R-HSA-8853136) p-6Y FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane] (R-HSA-8853130) p-6Y FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane] (R-HSA-8853133) p-6Y FGFR2 (22-767)-CCAR(51-923) fusion [plasma membrane] (R-HSA-8853141) p-8Y-FGFR2 K660N [plasma membrane] (R-HSA-2033301) p-8Y-FGFR2 N549H [plasma membrane] (R-HSA-2033304) p-8Y-FGFR2 N549K [plasma membrane] (R-HSA-2033306) p-8Y-FGFR2 [plasma membrane] (R-HSA-2029874) p-8Y-FGFR2 S267P [plasma membrane] (R-HSA-2029879) p-8Y-FGFR2 W290C [plasma membrane] (R-HSA-2029875) phosphorylated FGFR2 L764fs4 [plasma membrane] (R-HSA-2071957) p-8Y-FGFR2 K660E [plasma membrane] (R-HSA-2033298) p-8Y-FGFR2 K660M [plasma membrane] (R-HSA-2033300)	0.655	5
UniProt:P29350 PTPN6	5	PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [tertiary granule lumen] (R-HSA-6800952)	0.646	3
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.643	3
UniProt:Q8N1K5-1 THEMIS			0.639	10
UniProt:O14939 PLD2	2	PLD2 [endoplasmic reticulum membrane] (R-HSA-1498791) PLD2 [plasma membrane] (R-HSA-2029075)	0.635	4
UniProt:Q15027 ACAP1			0.635	3
UniProt:Q9H788 SH24A			0.621	3
UniProt:Q12774 ARHGEF5	1	ARHGEF5 [cytosol] (R-HSA-8873909)	0.613	4
UniProt:P06400 RB1	3	p-S795-RB1 [nucleoplasm] (R-HSA-69226) RB1 [nucleoplasm] (R-HSA-68642) p-RB1 [nucleoplasm] (R-HSA-188389)	0.61	4
UniProt:Q8NFH8-2 REPS2			0.602	8
UniProt:P34152 Ptk2	13	phospho-p-Y397-PTK2 [cytosol] (R-MMU-354068) phospho-p-6Y-PTK2 [cytosol] (R-MMU-354128) PTK2 [cytosol] (R-MMU-201621) PTK2(1-772) [cytosol] (R-MMU-202827) PTK2(773-1052) [cytosol] (R-MMU-202829) phospho-p-6Y,S732-PTK2 [cytosol] (R-MMU-5218694) phospho-p-5Y,S732-PTK2 [cytosol] (R-MMU-5229006) phospho-p-5Y-PTK2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) p-Y428-FAK1 [cytosol] (R-MMU-3928397) phospho-pY-PTK2 [cytosol] (R-MMU-9632393) phospho-p-Y194,Y397-PTK2 [cytosol] (R-MMU-8874600) phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-MMU-8874613)	0.597	3
UniProt:O15357 INPPL1	1	INPPL1 [cytosol] (R-HSA-913354)	0.597	4
UniProt:Q9ESJ4	1	NCKIPSD [cytosol] (R-MMU-2197671)	0.593	8
UniProt:O43597 SPRY2	8	p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) SPRY2 [plasma membrane] (R-HSA-182924) SPRY2 [cytosol] (R-HSA-182949) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55-SPRY2 [cytosol] (R-HSA-182950)	0.591	3
UniProt:O92972 POLG			0.589	2
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.589	3
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.573	2
UniProt:Q15303 ERBB4			0.573	7
UniProt:O14490 DLGAP1	1	DLGAP1 [plasma membrane] (R-HSA-6794239)	0.573	3
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.573	2
UniProt:P98082 DAB2	3	DAB2 [lysosomal membrane] (R-HSA-2980807) DAB2 [cytosol] (R-HSA-8862456) DAB2 [plasma membrane] (R-HSA-2980808)	0.573	2
UniProt:Q8IVH8 M4K3			0.573	2
UniProt:O15056 SYNJ2	1	SYNJ2 [cytosol] (R-HSA-1806193)	0.573	2
UniProt:Q5SXH7 PKHS1			0.57	3
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.57	3
UniProt:Q8TE12 LMX1A			0.57	3
UniProt:Q5BJH2-2 TMEM128			0.57	3
UniProt:Q9NPB6-2 PARD6A			0.57	3
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [cytosol] (R-HSA-1181251) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425)	0.57	3
UniProt:Q07869 PPARA	2	PPARA [nucleoplasm] (R-HSA-400186) SUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099)	0.57	3
UniProt:P14868 DARS	1	DARS [cytosol] (R-HSA-379605)	0.564	2
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.564	2
UniProt:P21333 FLNA	3	p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019) FLNA [extracellular region] (R-HSA-350712)	0.564	2
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.564	2
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.564	2
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q6P1W5 CA094			0.556	3
UniProt:Q9P2A4 ABI3			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q04864 REL	2	REL [nucleoplasm] (R-HSA-1168585) REL [cytosol] (R-HSA-1168579)	0.556	3
UniProt:Q12929 EPS8			0.556	3
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q7L190 DPPA4	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.556	3
UniProt:Q9BRR9 ARHGAP9	3	ARHGAP9 [extracellular region] (R-HSA-6806529) ARHGAP9 [cytosol] (R-HSA-2976572) ARHGAP9 [secretory granule lumen] (R-HSA-6804973)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q9GZT8 NIF3L			0.556	3
UniProt:Q92841 DDX17	2	SUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.556	3
IntAct:EBI-10220116 163154			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:O15156 ZBT7B			0.556	3
UniProt:P48634 PRC2A			0.553	2
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.553	2
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.553	2
UniProt:Q06187 BTK	6	p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) Active BTK [cytosol] (R-HSA-8964323) p-Y551-BTK [cytosol] (R-HSA-2685603) p-Y551-BTK [plasma membrane] (R-HSA-9606165) p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807) BTK [cytosol] (R-HSA-197948)	0.547	2
UniProt:Q5JSH3 WDR44			0.547	2
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.547	2
UniProt:P11021 HSPA5	6	HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190)	0.547	2
UniProt:Q8N1I0 DOCK4	1	DOCK4 [cytosol] (R-HSA-1012995)	0.547	2
UniProt:P19338 NCL	1	NCL [nucleoplasm] (R-HSA-6791213)	0.547	2
UniProt:Q05397 PTK2	11	p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) pY-PTK2 [cytosol] (R-HSA-9632393) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.547	2
UniProt:Q01082 SPTBN1	1	SPTBN1 [cytosol] (R-HSA-420048)	0.547	2
UniProt:P05787 KRT8	1	KRT8 [cytosol] (R-HSA-446043)	0.547	3
UniProt:Q92734 TFG	1	TFG [cytosol] (R-HSA-5688159)	0.547	2
UniProt:O75083 WDR1	2	WDR1 [cytosol] (R-HSA-350699) WDR1 [extracellular region] (R-HSA-350752)	0.547	2
UniProt:O43295 SRGAP3	1	SRGAP3 [cytosol] (R-HSA-428463)	0.544	2
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.544	2
UniProt:Q9UQ16-2 DNM3			0.527	2
UniProt:P42338 PIK3CB	1	PIK3CB [cytosol] (R-HSA-74788)	0.527	2
UniProt:P42336 PIK3CA	25	PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA M1043I [cytosol] (R-HSA-1500719) PIK3CA M1043T [cytosol] (R-HSA-2395934) PIK3CA M1043V [cytosol] (R-HSA-2395932) PIK3CA H1047Y [cytosol] (R-HSA-1500720) PIK3CA E542K [cytosol] (R-HSA-1500701) PIK3CA Q546K [cytosol] (R-HSA-1500705) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA E542Q [cytosol] (R-HSA-2328003) PIK3CA R38H [cytosol] (R-HSA-1500718) PIK3CA R38S [cytosol] (R-HSA-2395947) PIK3CA R38G [cytosol] (R-HSA-2395950) PIK3CA R38C [cytosol] (R-HSA-1500691) PIK3CA [cytosol] (R-HSA-74787)	0.527	2
UniProt:Q9H792 PEAK1			0.527	2
UniProt:O43426 SYNJ1	1	SYNJ1 [cytosol] (R-HSA-1604634)	0.527	2
UniProt:Q75VX8 GARE2			0.527	2
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [nucleoplasm] (R-HSA-71929) HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.527	2
UniProt:A6NGB9 WIPF3	1	WIPF3 [cytosol] (R-HSA-2197670)	0.527	2
UniProt:P19105 MYL12A	2	MYL12A [cytosol] (R-HSA-390735) p-S19-MYL12A [cytosol] (R-HSA-390749)	0.527	2
UniProt:Q8TF42 UBS3B			0.527	3
UniProt:Q96RF0-2 SNX18			0.527	2
UniProt:Q38SD2 LRRK1			0.527	2
UniProt:Q13480-2 GAB1			0.527	2
UniProt:Q96JJ3 ELMO2	1	ELMO2 [cytosol] (R-HSA-372642)	0.527	2
UniProt:Q9H939 PPIP2			0.527	2
UniProt:Q96P48 ARAP1	2	ARAP1 [cytosol] (R-HSA-3211582) p-Y231-ARAP1 [cytosol] (R-HSA-8848869)	0.527	2
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.525	2
UniProt:P29353-1 SHC1	4	SHC1-1 [cytosol] (R-HSA-1433366) SHC1 [plasma membrane] (R-HSA-2404179) p-S139,3Y-SHC1-1 [cytosol] (R-HSA-8934452) p-Y349,Y350,Y427-SHC1-1 [cytosol] (R-HSA-2404176)	0.524	3
UniProt:P26662-PRO_0000037647			0.524	3
UniProt:O75674 TM1L1			0.524	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2(1-524) [plasma membrane] (R-HSA-164946) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.524	2
UniProt:Q7L0Q8 RHOU	2	RHOU [cytosol] (R-HSA-194901) RHOU [plasma membrane] (R-HSA-194914)	0.524	3
UniProt:Q66PJ3-4 ARL6IP4			0.508	2
UniProt:Q9Y478 PRKAB1	2	PRKAB1 [cytosol] (R-HSA-380968) PRKAB1 [nucleoplasm] (R-HSA-2151199)	0.508	2
UniProt:P54762 EPHB1	6	EPHB1 (?-984) [cytosol] (R-HSA-3928438) EPHB1 (?-?) [plasma membrane] (R-HSA-3928449) EPHB1 (?-984) [plasma membrane] (R-HSA-3928402) EPHB1 (18-?) [extracellular region] (R-HSA-3928393) EPHB1 [plasma membrane] (R-HSA-2682340) p-Y594,Y600-EPHB1 [plasma membrane] (R-HSA-3928347)	0.499	2
UniProt:Q9H0X6 RN208			0.488	2
UniProt:Q8N7B6-2 PACRGL			0.488	2
UniProt:Q9NRF2-2 SH2B1	1	SH2B1-2 [cytosol] (R-HSA-1675482)	0.488	2
UniProt:Q7Z783 Q7Z783			0.488	2
UniProt:Q49A26-4 GLYR1			0.488	2
UniProt:Q9H7T9 AUNIP			0.488	2
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.488	2
UniProt:Q96D37 Q96D37			0.488	2
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.488	2
UniProt:Q9BUN5-3 CCDC28B			0.488	2
UniProt:Q5T749 KPRP			0.488	2
UniProt:A2RU56 A2RU56			0.488	2
UniProt:Q86UU5 GGN			0.488	2
UniProt:Q9BYN7 ZN341			0.488	2
UniProt:Q6DHY5 TBC3G			0.488	2
UniProt:Q9NP98 MYOZ1			0.488	2
UniProt:P42681 TXK	3	TXK [cytosol] (R-HSA-3448733) p-Y91,Y420-TXK [cytosol] (R-HSA-3448740) p-Y420-TXK [cytosol] (R-HSA-3448734)	0.488	2
UniProt:O95994 AGR2			0.488	2
UniProt:A0JLT2-2 MED19			0.488	2
UniProt:Q92558 WASF1	3	p-Y151,S,T-WASF1 [cytosol] (R-HSA-5672390) p-Y151-WASF1 [cytosol] (R-HSA-2029058) WASF1 [cytosol] (R-HSA-200965)	0.488	2
UniProt:Q03989 ARI5A			0.488	2
UniProt:Q9Y330 ZBT12			0.488	2
UniProt:Q9Y5E4 PCDB5			0.488	2
UniProt:Q6IQ23-2 PLEKHA7			0.488	2
UniProt:Q8N9I9 DTX3			0.488	2
UniProt:Q86SG2 ANR23			0.488	2
UniProt:Q9HB07 MYG1			0.488	2
UniProt:Q96ID7 Q96ID7			0.488	2
UniProt:Q9BRT2 UQCC2			0.488	2
IntAct:EBI-12022818 PRR22			0.488	2
UniProt:Q96D03 DDT4L			0.488	2
UniProt:B1AHC3 B1AHC3			0.488	2
UniProt:Q8N684-3 CPSF7			0.488	2
UniProt:Q06418 TYRO3			0.488	2
UniProt:Q8IZQ1 WDFY3			0.488	2
UniProt:Q6S9Z5 ZN474			0.488	2
UniProt:Q96SW2-2 CRBN			0.488	2
UniProt:O14512 SOCS7			0.488	2
UniProt:Q5JST6 EFHC2			0.488	2
UniProt:Q8N448 LNX2			0.488	2
UniProt:O14641 DVL2	5	p-DVL2 [cytosol] (R-HSA-201706) pp-DVL2 [cytosol] (R-HSA-3772398) DVL2 [cytosol] (R-HSA-201694) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.488	2
UniProt:Q5SQ64 LY6G6F	2	LY6G6F [platelet alpha granule membrane] (R-HSA-8862968) LY6G6F [plasma membrane] (R-HSA-8862974)	0.462	2
UniProt:P09619 PDGFRB	3	PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.462	2
UniProt:P12497-PRO_0000042399 GAG-POL			0.462	3
UniProt:A9UF07 A9UF07			0.462	6
UniProt:P30530 AXL	2	p-Y772,Y814-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.462	3