STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex

Stable Identifier
R-HSA-8983059
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
TSLP:IL7R:CRLF2 phosphorylates STAT3
ReviewStatus
5/5
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Inferred from mouse:
Following binding of TSLP to Cytokine receptor-like factor 2 (CRLF2, TSLPR) and Interleukin-7 receptor subunit alpha (IL7R), Signal transducer and activator of transcription 5A and 5B (STAT5A and STAT5B) and Signal transducer and activator of transcription 3 (STAT3) were phosphorylated in various Ba/F3 cell populations (Reche et al. 2001).
This is a black box event since the kinase responsible for STAT phosphorylation is unknown.
Literature References
PubMed ID Title Journal Year
11418668 Human thymic stromal lymphopoietin preferentially stimulates myeloid cells

Bazan, JF, Johnston, J, Zurawski, SM, de Waal Malefyt, R, Gorman, DM, Liu, MR, Liu, YJ, Clifford, T, Kastelein, RA, Travis, M, Spits, H, Soumelis, V, Reche, PA

J. Immunol. 2001
Participants
Participates
Catalyst Activity

transmembrane receptor protein kinase activity of IL7R:TSLP:CRLF2:STAT3 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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