CCNE1 gene transcription is stimulated by E2F1

Stable Identifier
R-HSA-8961846
Type
Reaction [omitted]
Species
Homo sapiens
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E2F1 directly stimulates transcription of the CCNE1 gene, encoding cyclin E1 (DeGregori et al. 1995, Ohtani et al. 1995).Cyclin E proteins play an important role in the transition from G1 to S-phase by associating with CDK2.

Literature References
PubMed ID Title Journal Year
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

DeGregori, J, Kowalik, T, Nevins, JR

Mol Cell Biol 1995
8618861 Regulation of the cyclin E gene by transcription factor E2F1

Ohtani, K, DeGregori, J, Nevins, JR

Proc Natl Acad Sci U S A 1995
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