Reactome | Phosphorylated FUNDC1 links damaged mitochondria to LC3

Phosphorylated FUNDC1 links damaged mitochondria to LC3

Stable Identifier

R-HSA-8959573

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Phosphorylated FUNDC1 links damaged mitochondria to LC3

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

s17 Phosphorylated FUNDC1 links to the microtubule-associated protein Autophagy marker Light Chain 3 (LC3). This begins the recruitment of the autophagy machinery to the damaged mitochondria, targeting it for autophagic degradation.

Literature References

PubMed ID	Title	Journal	Year
22267086	Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells Feng, D, Chen, Q, Qi, W, Zhu, C, Sui, S, Wang, J, Xue, P, Jin, H, Wang, X, Li, B, Zheng, Q, Liu, P, Liu, L, Wang, R, Song, P, Ma, Q, Huang, L, Chen, M, Zhu, Y, Chen, G, Yang, F	Nat. Cell Biol.	2012