Reactome | RCN1 [endoplasmic reticulum lumen]

RCN1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956758

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Reticulocalbin-1, RCN1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15293 RCN1

Gene Names

RCN1, RCN

Chain

signal peptide:1-29, chain:30-331

Reference Genes

BioGPS Gene:5954 RCN1

COSMIC (genes):RCN1 RCN1

CTD Gene:5954 RCN1

dbSNP Gene:5954 RCN1

ENSEMBL:ENSG00000049449 RCN1

ENSEMBL_homo_sapiens_GENE:ENSG00000049449.10 RCN1

HGNC:9934 RCN1

KEGG Gene (Homo sapiens):5954 RCN1

Monarch:5954 RCN1

NCBI Gene:5954 RCN1

OMIM:602735 RCN1

UCSC:Q15293 RCN1

Reference Transcript

RefSeq:NM_002901.2 RCN1

Other Identifiers

11716791_a_at

11716792_s_at

11751509_a_at

16723246

201063_PM_at

201063_at

2963636

3325504

3325505

3325509

3325510

3325511

3325513

3325517

3325518

3325519

3325520

3325521

3512577

3512586

3512588

3512590

40556_at

49339_s_at

5954

7939120

A_14_P109022

A_23_P203299

D42073_at

GE56310

GO:0001701

GO:0005509

GO:0005515

GO:0005783

GO:0005788

GO:0043010

GO:0043226

GO:0046872

GO:0048856

HMNXSV003057228

ILMN_1800276

PH_hs_0010062

TC11000304.hg

TC13000633.hg

g4506454_3p_at

Participates

as a member of

FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

p-RCN1 [endoplasmic reticulum lumen]

Inferred To

scf [endoplasmic reticulum lumen] (Drosophila melanogaster)

RCN1 [endoplasmic reticulum lumen] (Bos taurus)

RCN1 [endoplasmic reticulum lumen] (Canis familiaris)

RCN1 [endoplasmic reticulum lumen] (Gallus gallus)

RCN1 [endoplasmic reticulum lumen] (Mus musculus)

RCN1 [endoplasmic reticulum lumen] (Sus scrofa)

Rcn1 [endoplasmic reticulum lumen] (Rattus norvegicus)

calu-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

rcn1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_002892.1

OpenTargets

ENSG00000049449

GeneCards

Q15293

HPA

ENSG00000049449-RCN1

Ensembl

ENST00000054950, ENSG00000049449, ENSP00000054950

PRO

Q15293

Pharos - Targets

Q15293

HMDB Protein

HMDBP07964

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	13
UniProt:Q969Y2 GTPBP3	1	GTPBP3 [mitochondrial matrix] (R-HSA-6787414)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.499	2

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