RUNX1 binds YAP1

Stable Identifier
R-HSA-8956639
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX1 binds YAP1
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RUNX1, presumably in complex with CBFB, binds to YAP1 (Levy, Adamovich et al. 2008; Levy, Reuven and Shaul 2008). Phosphorylation of YAP1 by ABL1 in response to DNA damage prevents binding of YAP1 to RUNX1 (Levy, Adamovich et al. 2008).
Literature References
PubMed ID Title Journal Year
18701449 A regulatory circuit controlling Itch-mediated p73 degradation by Runx

Shaul, Y, Reuven, N, Levy, D

J. Biol. Chem. 2008
18280240 Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

Shaul, Y, Reuven, N, Adamovich, Y, Levy, D

Mol. Cell 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
p-S456-ABL1 [nucleoplasm] (Homo sapiens)
Orthologous Events
RUNX1 binds YAP1 (Bos taurus)
RUNX1 binds YAP1 (Caenorhabditis elegans)
RUNX1 binds YAP1 (Canis familiaris)
RUNX1 binds YAP1 (Gallus gallus)
RUNX1 binds YAP1 (Mus musculus)
RUNX1 binds YAP1 (Rattus norvegicus)
RUNX1 binds YAP1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2017-01-24)
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