Reactome | AcM-UBE2M transfers NEDD8 to CUL9:RBX1

AcM-UBE2M transfers NEDD8 to CUL9:RBX1

Stable Identifier

R-HSA-8956025

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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UBE2M transfers NEDD8 to lysine 1881 of CUL9 (Skaar et al, 2007; Li et al, 2014). Neddylation increases the ubiquitination activity of the E3 complex towards its targets (Hori et al, 1999; Duda et al, 2008). One defined target of CUL9 is BIRC5 (also known as Survivin), which has roles in cellular proliferation, inhibition of apoptosis and maintenance of genome stability (Zhao et al, 2000; Watanabe, 2010). CUL9-mediated ubiquitination of BIRC5 is negatively regulated by the 3M complex, consisting of CUL7, CCDC8 and OBSL1 (Li et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
17332328	PARC and CUL7 form atypical cullin RING ligase complexes Tron, A, Florens, L, Tsutsumi, T, Skaar, JR, Swanson, SK, Arai, T, DeCaprio, JA, Washburn, MP	Cancer Res.	2007
10597293	Covalent modification of all members of human cullin family proteins by NEDD8 Kato, S, Shimbara, N, Miyamoto, C, Osaka, F, Okabayashi, K, Chiba, T, Tanaka, K, Hori, T	Oncogene	1999
24793696	CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity Pei, XH, Yan, J, Li, Z, Xiong, Y, Yan, F, Cappell, KM, Whitehurst, AW	Mol. Cell	2014
21447816	Temporal and spatial regulation of targeting aurora B to the inner centromere Watanabe, Y	Cold Spring Harb. Symp. Quant. Biol.	2010
11069780	The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner Downward, J, Lemoine, NR, Martins, LM, Tenev, T, Zhao, J	J. Cell. Sci.	2000
18805092	Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation Borg, LA, Hunt, HW, Duda, DM, Schulman, BA, Hammel, M, Scott, DC	Cell	2008