SOCS4 gene expression is inhibited by RUNX1

Stable Identifier
R-HSA-8955893
Type
Reaction [omitted]
Species
Homo sapiens
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ReviewStatus
5/5
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RUNX1, presumably in complex with CBFB, inhibits transcription of the SOCS4 gene. As SOCS4 is an inhibitor of STAT3, RUNX1-mediated repression of SOCS4 increases STAT3 activity, which is implicated in development of epithelial cancers (Scheitz et al. 2012).
Literature References
PubMed ID Title Journal Year
23034403 Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer

Lee, TS, Tumbar, T, McDermitt, DJ, Scheitz, CJ

EMBO J. 2012
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