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PHB2 [mitochondrial inner membrane]
Stable Identifier
R-HSA-8953721
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Prohibitin-2, PHB2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to mitochondrial stress (Homo sapiens)
OMA1 cleaves DELE1 (Homo sapiens)
PHB2:STOML2 [mitochondrial inner membrane] (Homo sapiens)
PHB2 [mitochondrial inner membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Mitochondrial calcium ion transport (Homo sapiens)
Processing of SMDT1 (Homo sapiens)
AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 ring [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB2 [mitochondrial inner membrane] (Homo sapiens)
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 ring [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB2 [mitochondrial inner membrane] (Homo sapiens)
proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 ring [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB2 [mitochondrial inner membrane] (Homo sapiens)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 ring [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB2 [mitochondrial inner membrane] (Homo sapiens)
proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 ring [mitochondrial inner membrane] (Homo sapiens)
PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB2 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99623 PHB2
Gene Names
PHB2, BAP, REA
Chain
initiator methionine:, chain:2-299
Reference Genes
BioGPS Gene:11331 PHB2
COSMIC (genes):PHB2 PHB2
CTD Gene:11331 PHB2
dbSNP Gene:11331 PHB2
ENSEMBL:ENSG00000215021 PHB2
ENSEMBL_homo_sapiens_GENE:ENSG00000215021.10 PHB2
HGNC:30306 PHB2
KEGG Gene (Homo sapiens):11331 PHB2
Monarch:11331 PHB2
NCBI Gene:11331 PHB2
OMIM:610704 PHB2
UCSC:Q99623 PHB2
Reference Transcript
RefSeq:NM_001144831.1 PHB2
RefSeq:NM_001267700.1 PHB2
Other Identifiers
11331
11715383_a_at
11715384_x_at
11753313_a_at
16760649
201600_PM_at
201600_at
3442397
3442402
3442405
3442412
3442414
3442415
3442418
3442421
3442423
3442424
37364_at
7960716
A_23_P151106
A_33_P3368328
GE54942
GO:0000278
GO:0000423
GO:0002376
GO:0002639
GO:0005515
GO:0005634
GO:0005737
GO:0005739
GO:0005741
GO:0005743
GO:0005886
GO:0006091
GO:0006351
GO:0006355
GO:0006606
GO:0006629
GO:0006886
GO:0006913
GO:0006914
GO:0007005
GO:0007062
GO:0007202
GO:0008289
GO:0009986
GO:0012501
GO:0014069
GO:0016020
GO:0016363
GO:0016477
GO:0022414
GO:0023035
GO:0023052
GO:0030331
GO:0030424
GO:0030520
GO:0031536
GO:0032991
GO:0033147
GO:0033218
GO:0033598
GO:0033600
GO:0035632
GO:0036211
GO:0039529
GO:0042113
GO:0042802
GO:0042803
GO:0043066
GO:0043226
GO:0043433
GO:0045892
GO:0046625
GO:0046982
GO:0048786
GO:0048856
GO:0048870
GO:0050821
GO:0051091
GO:0055085
GO:0060744
GO:0060749
GO:0060762
GO:0070374
GO:0071300
GO:0071456
GO:0071944
GO:0098542
GO:0098800
GO:0098978
GO:0098982
GO:0110165
GO:0140014
GO:0140374
GO:1900208
GO:1901224
GO:1902808
GO:1904959
GO:1990051
HMNXSV003058162
ILMN_1696087
PH_hs_0025971
TC12001153.hg
U72511_at
g6005853_3p_at
Participates
as a component of
PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
PHB2:STOML2 [mitochondrial inner membrane] (Homo sapiens)
Inferred To
phb2 [mitochondrial inner membrane]
(Danio rerio)
phb2 [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
phb2 [mitochondrial inner membrane]
(Xenopus tropicalis)
phb-2 [mitochondrial inner membrane]
(Caenorhabditis elegans)
phbB [mitochondrial inner membrane]
(Dictyostelium discoideum)
PHB2 [mitochondrial inner membrane]
(Bos taurus)
PHB2 [mitochondrial inner membrane]
(Canis familiaris)
PHB2 [mitochondrial inner membrane]
(Gallus gallus)
PHB2 [mitochondrial inner membrane]
(Plasmodium falciparum)
PHB2 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
PHB2 [mitochondrial inner membrane]
(Sus scrofa)
Phb2 [mitochondrial inner membrane]
(Drosophila melanogaster)
Phb2 [mitochondrial inner membrane]
(Mus musculus)
Phb2 [mitochondrial inner membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001254629.1
,
NP_001138303.1
OpenTargets
ENSG00000215021
GeneCards
Q99623
HPA
ENSG00000215021-PHB2
Ensembl
ENSG00000215021
,
ENST00000440277
,
ENSP00000441875
,
ENST00000535923
,
ENSP00000412856
PRO
Q99623
Pharos - Targets
Q99623
PDB
6IQE
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35232 PHB
2
PHB [cytosol]
(R-HSA-5672944)
PHB [mitochondrial inner membrane]
(R-HSA-8953720)
0.589
3
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.508
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
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