Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate

Stable Identifier
R-HSA-8952137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phospholipid phosphatase 6 (PLPP6) dephosphorylates presqualene diphosphate (PSQPP) to presqualene monophosphate (PSMP). It may be indirectly involved in innate immunity, as PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. PLPP6 displays diphosphate phosphatase activity with a substrate preference PSDP > FDP > phosphatidic acid.
Literature References
PubMed ID Title Journal Year
16464866 Identification and functional characterization of a presqualene diphosphate phosphatase

Arita, M, Morris, AJ, Levy, BD, Fukunaga, K, Pfeffer, M, Takahashi, M

J. Biol. Chem. 2006
Participants
Participates
Catalyst Activity

hydrolase activity of PLPP6 [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!