RUNX3 binds TP53

Stable Identifier
R-HSA-8952128
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX3 binds TP53
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RUNX3 can bind to TP53 (p53). The interaction involves the C-termini of both RUNX3 and TP53. RUNX3 may act as a TP53 co-factor, stimulating TP53-mediated transcription of target genes, including CDKN1A (p21). RUNX3 may also interact with phosphorylated ATM kinase in response to DNA damage and facilitate ATM-mediated phosphorylation and stabilization of TP53 (Yamada et al. 2010).
Literature References
PubMed ID Title Journal Year
20353948 RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53

Kageyama, H, Ito, Y, Ozaki, T, Inoue, K, Kimura, H, Yamada, C, Miyazaki, M, Nakagawara, A, Okoshi, R, Suenaga, Y, Ando, K

J. Biol. Chem. 2010
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Orthologous Events
RUNX3 binds TP53 (Bos taurus)
RUNX3 binds TP53 (Canis familiaris)
RUNX3 binds TP53 (Danio rerio)
RUNX3 binds TP53 (Drosophila melanogaster)
RUNX3 binds TP53 (Mus musculus)
RUNX3 binds TP53 (Rattus norvegicus)
RUNX3 binds TP53 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-12-13)
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