Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1

Stable Identifier
R-HSA-8951690
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The DNA in the Pre-initiation complex is considerably compacted relative to its length when fully extended, probably due to binding of proteins in addition to the viral integrase. These proteins are not fully clarified, due to the difficulty of biochemical analysis of small amounts of material, but candidates include the viral NC and MA proteins, and the cellular HMGA, BAF, and PSIP1/LEDGF/p75 proteins. Purified integrase is capable of carrying out the terminal cleavage and initial strand transfer reactions.

Literature References
PubMed ID Title Journal Year
9188609 Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition

Miller, MD, Bushman, FD

J Virol 1997
9038339 HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro

Farnet, CM, Bushman, FD

Cell 1997
3032450 Correct integration of retroviral DNA in vitro

Brown, PO, Bowerman, B, Varmus, HE, Bishop, JM

Cell 1987
16291214 Retroviral DNA integration--mechanism and consequences

Lewinski, MK, Bushman, FD

Adv Genet 2005
16175173 Genome-wide analysis of retroviral DNA integration

Lewinski, M, Ciuffi, A, Barr, S, Leipzig, J, Hannenhalli, S, Hoffmann, C, Bushman, FD

Nat Rev Microbiol 2005
9860958 The barrier-to-autointegration protein is a host factor for HIV type 1 integration

Chen, H, Engelman, A

Proc Natl Acad Sci U S A 1998
  Retroviruses

Coffin, JM, Hughes, SH, Varmus, HE

  1997
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Cross References
Target Pathogen
Authored
Reviewed
Created