RUNX3 regulates WNT signaling

Stable Identifier
R-HSA-8951430
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RUNX3 regulates WNT signaling
Click the image above or here to open this pathway in the Pathway Browser
RUNX3 binds to complexes of beta-catenin (CTNNB1) and TCF/LEF family members. Binding of RUNX3 to CTNNB1:TCF/LEF complexes prevents their loading onto cyclin D1 (CCND1) and MYC gene promoters and interferes with WNT signaling-mediated activation of CCND1 and MYC1 transcription. RUNX3 therefore inhibits WNT-induced cellular proliferation (Ito et al. 2008).
Literature References
PubMed ID Title Journal Year
18772112 RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis

Ito, Y, Osato, M, Voon, DC, Lee, CW, Salto-Tellez, M, Fukamachi, H, Motoda, L, Chuang, LS, Wang, H, Ito, K, Lim, AC, Koo, JK

Cancer Cell 2008
Participants
Events
Participates
as an event of
Orthologous Events
RUNX3 regulates WNT signaling (Bos taurus)
RUNX3 regulates WNT signaling (Caenorhabditis elegans)
RUNX3 regulates WNT signaling (Canis familiaris)
RUNX3 regulates WNT signaling (Drosophila melanogaster)
RUNX3 regulates WNT signaling (Gallus gallus)
RUNX3 regulates WNT signaling (Mus musculus)
RUNX3 regulates WNT signaling (Rattus norvegicus)
RUNX3 regulates WNT signaling (Sus scrofa)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-12-02)
Cite Us!