Reactome | RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)

RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)

Stable Identifier

R-HSA-8951428

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)

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RUNX3 forms a ternary complex with beta-catenin (CTNNB1) and its binding partner TCF7L2 (TCF4). In addition to TCF7L2, RUNX3 is also able to interact with LEF1, TCF7L1 (TCF3) and TCF7 (also known as TCF1). The interaction involves the Runt domain of RUNX3 and the HMG box of TCF7L2 (Ito et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18772112	RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis Ito, Y, Osato, M, Voon, DC, Lee, CW, Salto-Tellez, M, Fukamachi, H, Motoda, L, Chuang, LS, Wang, H, Ito, K, Lim, AC, Koo, JK	Cancer Cell	2008