IL27 translocates from the cytosol to the extracellular space

Stable Identifier
R-HSA-8950674
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, extracellular region
Synonyms
Interleukin-27 subunit alpha traslocates to the extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IL27 translocates from the cytosol to the extracellular space
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Inferred from mouse:
Experiments in cells transfected with mouse Interleukin 27 subunit beta (Ebi3) and Interleukin 27 subunit alpha (Il27, IL27p28) showed that Il27 can be secreted as a monomer, whereas mouse Ebi3 protein is secreted only as heterodimers with Il27 (Shimozato et al. 2009). Il27, independently of Ebi3, can antagonize cytokine signaling through Interleukin 6 receptor subunit beta (Il6st, gp130) and Interleukin 6 (Il6) mediated production of Interleukin 17 (Il17) and Interleukin 10 (Il10) (Stumhofer et al. 2010).

This reaction is a black box event because the mechanism of Il27 translocation is unknown.
Participants
Input
Output
Participates
as an event of
Inferred From
Interleukin 27 translocates to the extracellular region (Mus musculus)
Authored
Duenas, C  (2016-12-02)
Reviewed
van de Vosse, E  (2017-05-12)
Created
Duenas, C  (2016-12-02)
Cite Us!