Reactome | CDKN1C [nucleoplasm]

CDKN1C [nucleoplasm]

Stable Identifier

R-HSA-8948130

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2, Kip2

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        CDKN1C [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49918 CDKN1C

Gene Names

CDKN1C, KIP2

Chain

chain:1-316

Reference Genes

BioGPS Gene:1028 CDKN1C

COSMIC (genes):CDKN1C CDKN1C

CTD Gene:1028 CDKN1C

dbSNP Gene:1028 CDKN1C

ENSEMBL:ENSG00000129757 CDKN1C

ENSEMBL_homo_sapiens_GENE:ENSG00000129757.15 CDKN1C

HGNC:1786 CDKN1C

KEGG Gene (Homo sapiens):1028 CDKN1C

Monarch:1028 CDKN1C

NCBI Gene:1028 CDKN1C

OMIM:600856 CDKN1C

UCSC:P49918 CDKN1C

Reference Transcript

Other Identifiers

1028

11729118_a_at

11763717_a_at

11763718_x_at

16734475

1787_at

213182_PM_x_at

213182_x_at

213348_PM_at

213348_at

216894_PM_x_at

216894_x_at

219534_PM_x_at

219534_x_at

3359434

3359435

3359436

3359437

3359438

3359439

3359440

3359441

3359442

3359443

3359444

3359445

38673_s_at

39545_at

7945767

GO:0000122

GO:0000278

GO:0001501

GO:0001822

GO:0001890

GO:0004860

GO:0004861

GO:0005515

GO:0005634

GO:0005737

GO:0006325

GO:0006351

GO:0006355

GO:0007049

GO:0007096

GO:0022414

GO:0023052

GO:0030099

GO:0030154

GO:0030325

GO:0030511

GO:0033673

GO:0035264

GO:0036211

GO:0042326

GO:0042551

GO:0043010

GO:0043226

GO:0044877

GO:0045892

GO:0045893

GO:0045930

GO:0048856

GO:0050680

GO:0051171

GO:0051726

GO:0055123

GO:0060065

GO:0060255

GO:0060669

GO:0071514

GO:0080090

GO:0098772

GO:0140014

GO:0140678

GO:1902746

GO:1904030

HMNXSV003055621

Hs.106070.1.S1_3p_at

Hs.106070.3.S1_3p_a_at

ILMN_1718565

PH_hs_0005906

TC11001284.hg

TC11003009.hg

U22398_at

Participates

as a candidate of

CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-Y91-CDKN1C [cytosol]

CDKN1C [cytosol]

Inferred To

CDKN1C [nucleoplasm] (Bos taurus)

CDKN1C [nucleoplasm] (Canis familiaris)

CDKN1C [nucleoplasm] (Sus scrofa)

Cdkn1c [nucleoplasm] (Mus musculus)

Cdkn1c [nucleoplasm] (Rattus norvegicus)

dap [nucleoplasm] (Drosophila melanogaster)

cdknx [nucleoplasm] (Xenopus tropicalis)

cdkn1c [nucleoplasm] (Danio rerio)

Cross References

RefSeq

XP_016872577.1, NP_000067.1, NP_001116102.1, NP_001116103.1

OpenTargets

ENSG00000129757

HPA

ENSG00000129757-CDKN1C

GeneCards

P49918

Ensembl

ENST00000430149, ENST00000414822, ENST00000440480, ENSG00000129757, ENSP00000411552, ENSP00000411257, ENSP00000413720

PRO

P49918

Pharos - Targets

P49918

Orphanet

15425

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	2
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.527	2

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