Reactome | RUNX3 regulates NOTCH signaling

RUNX3 regulates NOTCH signaling

Stable Identifier

R-HSA-8941856

Type

Pathway

Species

Homo sapiens

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RUNX3 negatively regulates NOTCH signaling, which contributes to the tumor suppressor role of RUNX3 in hepatocellular carcinoma. RUNX3 binds the promoter of the JAG1 gene, encoding NOTCH ligand JAG1 and inhibits its transcription (Nishina et al. 2011). In addition, RUNX3 also binds to the NOTCH1 coactivator complex at the promoter of HES1, a NOTCH target gene, and inhibits HES1 transcription (Gao et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
19800882	RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells Gao, J, Chen, Y, Wu, KC, Liu, J, Zhao, YQ, Pan, YL, Du, R, Zheng, GR, Xiong, YM, Xu, HL, Fan, DM	Exp. Cell Res.	2010
21637926	Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling Nishina, S, Shiraha, H, Nakanishi, Y, Tanaka, S, Matsubara, M, Takaoka, N, Uemura, M, Horiguchi, S, Kataoka, J, Iwamuro, M, Yagi, T, Yamamoto, K	Oncol. Rep.	2011