RUNX2 regulates genes involved in differentiation of myeloid cells

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R-HSA-8941333
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Homo sapiens
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Both RUNX2 and RUNX1 can stimulate transcription of the LGALS3 gene, encoding Galectin-3 (Vladimirova et al. 2008, Zhang et al. 2009). Galectin 3 is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000). Galectin 3 is highly expressed in pituitary tumors and glioma (Vladimirova et al. 2008, Zhang et al. 2009).

Literature References
PubMed ID Title Journal Year
10816326 GALECTIN-3 expression in differentiating human myeloid cells

Le Marer, N

Cell Biol. Int. 2000
18438928 Runx2 is expressed in human glioma cells and mediates the expression of galectin-3

Vladimirova, V, Waha, A, L├╝ckerath, K, Pesheva, P, Probstmeier, R

J. Neurosci. Res. 2008
19020999 RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors

Zhang, HY, Jin, L, Stilling, GA, Ruebel, KH, Coonse, K, Tanizaki, Y, Raz, A, Lloyd, RV

Endocrine 2009
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