ITGBL1 gene expression is stimulated by RUNX2

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R-HSA-8939829
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Reaction [omitted]
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Homo sapiens
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Binding of RUNX2, presumably associated with CBFB, to RUNX2 response elements in the promoter of the ITGBL1 gene stimulates ITGBL1 transcription. ITGBL1 encodes Integrin beta-like protein 1, which is implicated in regulation of TGF-beta signaling and RUNX2-induced bone metastasis of breast cancer (Li et al. 2015).

Literature References
PubMed ID Title Journal Year
26060017 ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway

Li, XQ, Du, X, Li, DM, Kong, PZ, Sun, Y, Liu, PF, Wang, QS, Feng, YM

Cancer Res. 2015
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