Reactome | RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Stable Identifier

R-HSA-8939242

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

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The RUNX1:CBFB complex directly inhibits transcription of the SERPINB13 gene (Nomura et al. 2005), a gene involved in keratinocyte differentiation that is frequently down-regulated in head and neck cancers (Boyapati et al. 2011). RUNX1 also inhibits transcription of STAT3 inhibitors SOCS3 and SOCS4, resulting in elevated STAT3 activity. RUNX1-mediated increase in STAT3 activity, first discovered in keratinocytes, is thought to be involved in the maintenance of epithelial stem cells and contributes to development of epithelial cancers, including squamous cell carcinoma (SCC) of the skin (Scheitz et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
15751268	Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells Nomura, T, Katunuma, N	J. Med. Invest.	2005
21723253	SERPINB13 is a novel RUNX1 target gene Boyapati, A, Ren, B, Zhang, DE	Biochem. Biophys. Res. Commun.	2011
23034403	Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer Lee, TS, Tumbar, T, McDermitt, DJ, Scheitz, CJ	EMBO J.	2012