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PF4 gene transcription is stimulated by RUNX1:CBFB
Stable Identifier
R-HSA-8938174
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
platelet alpha granule lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
PF4 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)
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Binding of the RUNX1:CBFB complex to the promoter of the PF4 gene stimulates transcription of PF4. The PF4 gene encodes Platelet factor 4, a protein stored in platelet alpha granules. Deficiency of alpha granule proteins, including PF4, is the cause of gray platelet syndrome. PF4 deficiency can be caused by RUNX1 haploinsuficiency (Aneja et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
21129147
Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4
Rao, AK
,
Singh, A
,
Jalagadugula, G
,
Mao, G
,
Aneja, K
J. Thromb. Haemost.
2011
Participants
Input
PF4 gene [nucleoplasm]
(Homo sapiens)
Output
PF4 [platelet alpha granule lumen]
(Homo sapiens)
Participates
as an event of
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
This event is regulated
Positively by
Regulator
RUNX1:CBFB:PF4 gene [nucleoplasm]
(Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M (2016-09-14)
Reviewed
Chuang, LS (2016-12-20)
Ito, Y (2016-12-20)
Created
Orlic-Milacic, M (2016-09-08)
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