Reactome | RUNX3 translocates to the nucleus

RUNX3 translocates to the nucleus

Stable Identifier

R-HSA-8937814

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

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Translocation of RUNX3 from the cytosol to the nucleus is stimulated by TGF-beta (TGFB1) treatment (Ito et al. 2005) and inhibited by SRC-mediated phosphorylation of RUNX3 on multiple tyrosine residues (Goh et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
16140942	RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization Ito, K, Liu, Q, Salto-Tellez, M, Yano, T, Tada, K, Ida, H, Huang, C, Shah, N, Inoue, M, Rajnakova, A, Hiong, KC, Peh, BK, Han, HC, Ito, T, Teh, M, Yeoh, KG, Ito, Y	Cancer Res.	2005
20100835	Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm Goh, YM, Cinghu, S, Hong, ET, Lee, YS, Kim, JH, Jang, JW, Li, YH, Chi, XZ, Lee, KS, Wee, H, Ito, Y, Oh, BC, Bae, SC	J. Biol. Chem.	2010