Reactome | ATAD2 binds ESR1

ATAD2 binds ESR1

Stable Identifier

R-HSA-8937369

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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ATPase family AAA domain-containing protein 2 (ATAD2 aka ANCCA) is a highly conserved protein primarily located in the cell nucleus. Its protein structure consists of two AAA domains and one bromodomain, indicating roles related to genome regulation, such as acting on chromatin structure and function (Caron et al. 2010, Magnani & Lupien 2014). ATAD2 is highly expressed in multiple cancers (Krakstad et al. 2015, Ciro et al. 2009, ) and is a strong predictor of rapid mortality in lung and breast cancers sufferers (Caron et al. 2010). Additionally, ATAD2 functions as a co-activator of the estrogen receptor (ESR1) and the androgen receptor (Zou et al. 2009), implicating it as an oncogenic protein in hormone-related cancers such as breast cancer and prostate cancer (Zou et al. 2007). This reaction shows ATAD2 binding to ESR1.

Literature References

PubMed ID	Title	Journal	Year
23684889	Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling Magnani, L, Lupien, M	Mol. Cell. Endocrinol.	2014
19318566	Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer Guo, L, Kung, HJ, Gemo, AT, Tepper, CG, Revenko, AS, Chen, HW, Zou, JX	Cancer Res.	2009
26308378	ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma Stefansson, I, Kalland, KH, Halle, MK, Tangen, IL, Salvesen, HB, Berg, A, Werner, HM, Krakstad, C, Øyan, AM, Kusonmano, K, Trovik, J, Chen, HW, Zou, JX, Ræder, MB, Hoivik, EA	Oncotarget	2015
20581866	Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers Khochbin, S, Curtet, S, Lestrat, C, Rousseaux, S, Escoffier, E, Debernardi, A, Marsal, S, Brambilla, C, Virolle, V, Barbry, P, Caron, C, Brambilla, E	Oncogene	2010
17998543	ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification Gemo, AT, Revenko, AS, Chen, HW, Zou, JX, Li, LB	Proc. Natl. Acad. Sci. U.S.A.	2007
19843847	ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors Helin, K, McBlane, F, Christensen, J, Prosperini, E, Pacchiana, G, Quarto, M, Grazini, U, Walfridsson, J, Capra, M, Ciró, M, Nucifero, P	Cancer Res.	2009