PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter

Stable Identifier
R-HSA-8936608
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The histone arginine methyltransferase PRMT6 asymmetrically dimethylates histone H3 on arginine residue R2 (R3 when taking into account the initiator methionine), thus creating the H3R2me2a mark on nucleosomes at the GP1BA gene promoter. Histone H3 arginine methylation by PRMT6 interferes with methylation of H3K4me2 to generate the activating H3K4me3 mark at the GP1BA gene promoter, thus contributing to transcriptional repression (Herglotz et al. 2013).
Literature References
PubMed ID Title Journal Year
22777353 Histone arginine methylation keeps RUNX1 target genes in an intermediate state

Hussong, H, Herglotz, J, Kolodziej, S, Grez, M, Kuvardina, ON, Kumar, A, Lausen, J

Oncogene 2013
Participants
Participates
Catalyst Activity

histone H3 methyltransferase activity of RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!