Reactome | SOCS4 [cytosol]

SOCS4 [cytosol]

Stable Identifier

R-HSA-8936109

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Suppressor of cytokine signaling 4, SOCS4_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q92569 PIK3R3

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (Homo sapiens)
        
        SOCS4 gene expression is inhibited by RUNX1 (Homo sapiens)
        
        SOCS4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WXH5 SOCS4

Gene Names

SOCS4, SOCS7

Chain

chain:1-440

Reference Genes

BioGPS Gene:122809 SOCS4

COSMIC (genes):SOCS4 SOCS4

CTD Gene:122809 SOCS4

dbSNP Gene:122809 SOCS4

ENSEMBL:ENSG00000180008 SOCS4

HGNC:19392 SOCS4

KEGG Gene (Homo sapiens):122809 SOCS4

Monarch:122809 SOCS4

NCBI Gene:122809 SOCS4

OMIM:616337 SOCS4

UCSC:Q8WXH5 SOCS4

Reference Transcript

Other Identifiers

0001400451

0005550692

11736895_s_at

11739980_a_at

11739981_s_at

11752167_a_at

122809

13478

1552792_at

16784367

226178_at

2IZV

3536651

3536652

3536653

3536654

3536656

3536657

3536658

3536659

3536660

3536661

3536662

3536664

3536665

3536666

3536667

3536668

45116_at

57961

7974447

A_14_P114190

A_14_P124778

A_23_P151700

A_24_P90637

A_33_P3349334

AAH60790

AAL60517

AF424815

BC060790

BX161418

CAB013478

CAD61893

CAI45958

CCDS9722

CH471061

CR933659

DKFZp686J1568

EAW80655

ENSG00000180008

ENSP00000341327

ENSP00000378855

ENSP00000452522

ENST00000339298

ENST00000339298.2

ENST00000395472

ENST00000395472.2

ENST00000555846

ENST00000555846.1

EntrezGene:122809

EntrezGene:SOCS4

GE514642

GE563681

GE870991

GO:0003674

GO:0005515

GO:0005575

GO:0005942

GO:0006464

GO:0006629

GO:0007165

GO:0007175

GO:0008150

GO:0009056

GO:0009968

GO:0016567

GO:0030234

GO:0032436

GO:0032991

GO:0035556

GO:0040007

GO:0040008

GO:0043551

GO:0046854

GO:0046935

HGNC:19392

HPA057961

Hs.34789.1.A1_3p_at

Hs2.352327.1.S1_3p_at

ILMN_1706216

ILMN_1753795

ILMN_2413259

ILMN_2413264

IPR000980

IPR001496

IPR022252

IPR028416

IPR035864

IPR036036

IPR036860

IPR037342

MIM:616337

NM_080867

NM_199421

NP_543143

NP_955453

PF00017

PF07525

PF12610

PH_hs_0016858

PH_hs_0029833

Q5H9R6

SM00252

SM00253

SM00969

SOCS4

SOCS4-201

SOCS4-202

SOCS4-204

TC14000321.hg

UPI000000CC33

XM_011536425

XM_011536426

XP_011534727

XP_011534728

Participant Of

output

SOCS4 gene expression is inhibited by RUNX1

Cross References

RefSeq

XP_011534728.1, NP_543143.1, XP_011534727.1, NP_955453.1

OpenTargets

ENSG00000180008

GeneCards

Q8WXH5

PRO

Q8WXH5

PDB

2IZV

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.57	3
UniProt:Q96R05 RET7			0.57	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.57	3
UniProt:Q9BXM7 PINK1	4	PINK1 [cytosol] (R-HSA-5205637) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [mitochondrial outer membrane] (R-HSA-5205653)	0.57	3
UniProt:O43559 FRS3	3	FRS3 [plasma membrane] (R-HSA-191482) p-5Y-FRS3 [plasma membrane] (R-HSA-191475) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.508	2
UniProt:Q8WW24 TEKT4			0.488	2
UniProt:O75829-2 CNMD			0.488	2
IntAct:EBI-10696539 PPAPDC2			0.488	2
UniProt:Q07912 ACK1			0.488	2
UniProt:Q8N3R9 MPP5	1	MPP5 [plasma membrane] (R-HSA-419969)	0.488	2
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.488	2