miR-302b binds RUNX1 mRNA

Stable Identifier
R-HSA-8935864
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Mature single stranded microRNA miR-302b-3p, one of the two products of miR-302b encoded by the MIR302B gene, binds to the 3'UTR of RUNX1 mRNA, which results in decreased RUNX1 mRNA and protein levels. As it affects RUNX1 mRNA levels, miR-302b is assumed to function as a component of the endonucleolytic RISC, but it is possible that it additionally functions as a component of the nonendonucleolytic RISC. Levels of miR-302b are decreased in epithelial ovarian carcinoma (Ge et al. 2014).
Literature References
PubMed ID Title Journal Year
25562167 MicroRNA-302b suppresses human epithelial ovarian cancer cell growth by targeting RUNX1

Lou, G, Yang, M, Ge, T, Liu, T, Yin, M

Cell. Physiol. Biochem. 2014
Participants
Participates
Authored
Reviewed
Created
Cite Us!