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CBLL1 binds SRC-phosphorylated CDH1 complex
Stable Identifier
R-HSA-8876993
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
plasma membrane
,
peptidoglycan-based cell wall
,
cytosol
Synonyms
Hakai binds SRC-phosphorylated E-cadherin complex
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Listeria monocytogenes entry into host cells (Homo sapiens)
InlA-mediated entry of Listeria monocytogenes into host cells (Homo sapiens)
CBLL1 binds SRC-phosphorylated CDH1 complex (Homo sapiens)
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CBL-like E3 ubiquitin ligase Hakai (CBLL1) binds to SRC-phosphorylated E-cadherin (CDH1) complex bound to Listeria monocytogenes cell wall protein InlA (Bonazzi et al. 2008). SRC-mediated phosphorylation of CDH1 complex on tyrosine residues Y753 and Y754 of CDH1 and an unknown tyrosine of beta-catenin (CTNNB1) at cell-cell adhesion sites creates docking sites for CBLL1. CBLL1 functions as zinc (Zn2+) coordinated homodimer. While CBLL1 interacts simultaneously with CDH1 and CTNNB1, CTNND1 (p120 catenin) is displaced by CBLL1 binding (Fujita et al. 2002, Mukherjee et al. 2012).
Literature References
PubMed ID
Title
Journal
Year
18624796
Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes
Pizarro-Cerdá, J
,
Bonazzi, M
,
Veiga, E
,
Cossart, P
Cell. Microbiol.
2008
Participants
Input
CBLL1 dimer:Zn2+ [cytosol]
(Homo sapiens)
InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CTNND1 [plasma membrane]
(Homo sapiens)
Output
CTNND1 [plasma membrane]
(Homo sapiens)
InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane]
(Homo sapiens)
Entity On Other Cell
InlA [peptidoglycan-based cell wall]
(Listeria monocytogenes)
Participates
as an event of
InlA-mediated entry of Listeria monocytogenes into host cells (Homo sapiens)
Disease
Name
Identifier
Synonyms
listeriosis
DOID:11573
Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Orlic-Milacic, M (2016-06-14)
Reviewed
Schwerk, C (2016-10-25)
Created
Orlic-Milacic, M (2016-06-17)
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