Reactome | MyrG-SRC [plasma membrane]

MyrG-SRC [plasma membrane]

Stable Identifier

R-HSA-8876922

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Icon

Locations in the PathwayBrowser for interactor UniProt:Q68CZ2 TNS3

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External Reference Information

External Reference

UniProt:P12931 SRC

Gene Names

SRC, SRC1

Chain

initiator methionine:1, chain:2-536

Reference Genes

BioGPS Gene:6714 SRC

COSMIC (genes):SRC SRC

CTD Gene:6714 SRC

dbSNP Gene:6714 SRC

ENSEMBL:ENSG00000197122 SRC

HGNC:11283 SRC

KEGG Gene (Homo sapiens):6714 SRC

Monarch:6714 SRC

NCBI Gene:6714 SRC

OMIM:190090 SRC

UCSC:P12931 SRC

Reference Transcript

Other Identifiers

0002970286

0003290040

11723135_s_at

11723136_x_at

1558211_s_at

16913413

1938_at

1A07

1A08

1A09

1A1A

1A1B

1A1C

1A1E

1FMK

1HCS

1HCT

1KSW

1O41

1O42

1O43

1O44

1O45

1O46

1O47

1O48

1O49

1O4A

1O4B

1O4C

1O4D

1O4E

1O4F

1O4G

1O4H

1O4I

1O4J

1O4K

1O4L

1O4M

1O4N

1O4O

1O4P

1O4Q

1O4R

1SHD

1Y57

1YI6

1YOJ

1YOL

1YOM

213324_at

221284_s_at

2BDF

2BDJ

2H8H

2SRC

30875

3884193

3884196

3884198

3884199

3884200

3884202

3884203

3884207

3884209

3884210

3884214

3884215

3884216

3884221

3884223

3884227

3884228

3884229

38904_at

3VRO

3ZMP

3ZMQ

4023

4F59

4F5A

4F5B

4HXJ

4K11

4MXO

4MXX

4MXY

4MXZ

6714

6ATE

6C4S

6EHJ

8062377

A_14_P111562

A_23_P308603

AAA60584

AAH11566

AAH51270

AL133293

BC011566

BC051270

CAA26485

CAB004023

CCDS13294

CH471077

EAW76064

EAW76065

EAW76066

EAW76067

ENSG00000197122

ENSP00000350941

ENSP00000362659

ENSP00000362668

ENSP00000362680

ENST00000358208

ENST00000358208.8

ENST00000373558

ENST00000373558.2

ENST00000373567

ENST00000373567.6

ENST00000373578

ENST00000373578.6

EntrezGene:6714

EntrezGene:SRC

g4885608_3p_a_at

GE81507

GO:0000003

GO:0000166

GO:0000902

GO:0001545

GO:0002102

GO:0002223

GO:0002376

GO:0003013

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005070

GO:0005080

GO:0005102

GO:0005158

GO:0005178

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005901

GO:0005975

GO:0006259

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006914

GO:0006950

GO:0007010

GO:0007049

GO:0007155

GO:0007165

GO:0007169

GO:0007172

GO:0007173

GO:0007179

GO:0007186

GO:0007229

GO:0007267

GO:0007411

GO:0008022

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0009612

GO:0009615

GO:0010447

GO:0010628

GO:0010632

GO:0010634

GO:0010641

GO:0010907

GO:0010954

GO:0014068

GO:0014069

GO:0014911

GO:0015031

GO:0016020

GO:0016032

GO:0016192

GO:0016236

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0018105

GO:0018108

GO:0019899

GO:0019900

GO:0019901

GO:0019904

GO:0020037

GO:0022407

GO:0022607

GO:0030154

GO:0030168

GO:0030331

GO:0030674

GO:0030900

GO:0031234

GO:0031295

GO:0031410

GO:0031625

GO:0031648

GO:0031667

GO:0031954

GO:0032148

GO:0032211

GO:0032463

GO:0032587

GO:0032869

GO:0032991

GO:0033146

GO:0033625

GO:0034330

GO:0034332

GO:0034446

GO:0034614

GO:0034641

GO:0035306

GO:0035556

GO:0035635

GO:0036035

GO:0036120

GO:0038083

GO:0038096

GO:0038128

GO:0040007

GO:0040011

GO:0042127

GO:0042169

GO:0042476

GO:0042493

GO:0042542

GO:0042592

GO:0043005

GO:0043065

GO:0043066

GO:0043114

GO:0043149

GO:0043154

GO:0043167

GO:0043226

GO:0043393

GO:0043406

GO:0043552

GO:0044281

GO:0044325

GO:0044403

GO:0044877

GO:0045056

GO:0045124

GO:0045296

GO:0045453

GO:0045737

GO:0045785

GO:0045892

GO:0045893

GO:0046628

GO:0046777

GO:0046875

GO:0048010

GO:0048011

GO:0048013

GO:0048471

GO:0048477

GO:0048856

GO:0048870

GO:0050715

GO:0050731

GO:0050839

GO:0050847

GO:0050877

GO:0050900

GO:0051057

GO:0051219

GO:0051222

GO:0051276

GO:0051385

GO:0051602

GO:0051604

GO:0051895

GO:0051897

GO:0051902

GO:0051974

GO:0060065

GO:0060444

GO:0060491

GO:0065003

GO:0070062

GO:0070301

GO:0070374

GO:0070542

GO:0070555

GO:0070700

GO:0070851

GO:0071222

GO:0071253

GO:0071375

GO:0071393

GO:0071398

GO:0071456

GO:0071498

GO:0071560

GO:0071803

GO:0071902

GO:0086098

GO:0090263

GO:0097110

GO:0098609

GO:0098962

GO:0098978

GO:0099091

GO:1900182

GO:1902533

GO:1903997

GO:2000386

GO:2000394

GO:2000573

GO:2000588

GO:2000641

GO:2000811

GO:2001237

GO:2001243

GO:2001286

HGNC:11283

HPA030875

Hs.198298.0.S1_3p_at

Hs2.383588.1.A1_3p_s_at

ILMN_1685898

ILMN_1729987

IPR000719

IPR000980

IPR001245

IPR001452

IPR008266

IPR011009

IPR017441

IPR020635

IPR036028

IPR036860

K03212

K03213

K03214

K03215

K03216

K03217

K03218

K03218_at

LRG_1018

LRG_1018t1

M16237

M16243

M16244

M16245

MIM:114500

MIM:190090

MIM:616937

NM_005417

NM_198291

NP_005408

NP_938033

PF00017

PF00018

PF07714

PH_hs_0033377

PR00109

PR00401

PR00452

SM00219

SM00252

SM00326

SRC

SRC-201

SRC-202

SRC-203

SRC-204

TC20000273.hg

TC20001205.hg

UPI0000000CB3

UPI0000000D75

X02647

X03995

X03996

X03997

X03998

X03999

X04000

XM_011529013

XM_017028024

XM_017028025

XM_017028026

XM_017028027

XP_011527315

XP_016883513

XP_016883514

XP_016883515

XP_016883516

Participant Of

hasComponent

input

Other forms of this molecule

SRC [cytosol]

p-Y416-SRC [cytosol]

p-Y419-SRC [nucleoplasm]

MyrG,p-Y530-SRC [plasma membrane]

MyrG-p-Y419-SRC [plasma membrane]

Inferred To

MyrG-SRC [plasma membrane] (Bos taurus)

MyrG-SRC [plasma membrane] (Caenorhabditis elegans)

MyrG-SRC [plasma membrane] (Canis familiaris)

MyrG-SRC [plasma membrane] (Danio rerio)

MyrG-SRC [plasma membrane] (Gallus gallus)

MyrG-SRC [plasma membrane] (Mus musculus)

MyrG-SRC [plasma membrane] (Rattus norvegicus)

MyrG-SRC [plasma membrane] (Sus scrofa)

MyrG-SRC [plasma membrane] (Xenopus tropicalis)

Ghost homologue of MyrG-SRC [plasma membrane] (Drosophila melanogaster)

Modified Residues

Name

N-myristoylglycine at 2

Coordinate

PsiMod Name

N-myristoylglycine [MOD:00068]

PsiMod Definition

A protein modification that effectively converts a glycine residue to N-myristoylglycine.

Cross References

RefSeq

XP_016883515.1, NP_938033.1, XP_016883514.1, XP_011527315.1, NP_005408.1, XP_016883516.1, XP_016883513.1

ZINC - World Drugs

SRC_HUMAN

OpenTargets

ENSG00000197122

ZINC - FDA approved

SRC_HUMAN

ZINC - Substances

SRC_HUMAN

ZINC target

P12931

ZINC - Biogenic

SRC_HUMAN

PRO

P12931

PDB

1O44, 2BDF, 1A1E, 1O4L, 6ATE, 1O4I, 1A09, 1YOL, 3ZMQ, 1O4F, 1O4K, 6E6E, 1O4P, 1O43, 1O49, 1O4H, 4F5B, 1O4M, 1O4B, 1YOJ, 1O45, 1O4G, 1KSW, 1Y57, 1O4A, 1HCT, 4MXO, 1O47, 6C4S, 1A1A, 1O4R, 1YI6, 1O4C, 4MXY, 1O41, 1FMK, 6EHJ, 2H8H, 2SRC, 1HCS, 4F5A, 1O4N, 4HXJ, 4K11, 2BDJ, 4MXZ, 1O46, 1O4E, 4MXX, 1YOM, 3VRO, 1A08, 1A1C, 1O48, 1O4J, 1O4Q, 3ZMP, 4F59, 1O42, 1A07, 1A1B, 1O4O, 1O4D, 1SHD

ZINC - Investigational

SRC_HUMAN

ZINC - Metabolites

SRC_HUMAN

IntEnz

2.7.10.2

GeneCards

P12931

ZINC - Predictions - Purchasable

SRC_HUMAN

Orphanet

25273

Interactors (54)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.937	14
UniProt:Q05397 PTK2	11	PTK2(773-1052) [cytosol] (R-HSA-202829) pY-PTK2 [cytosol] (R-HSA-9632393) PTK2(1-772) [cytosol] (R-HSA-202827) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.922	8
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.864	12
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.863	8
UniProt:P22681 CBL	6	p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940)	0.845	8
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.822	7
UniProt:P35968 KDR	2	p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103) VEGFR2 [plasma membrane] (R-HSA-195382)	0.77	6
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.75	4
UniProt:P15941 MUC1	19	Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) MUC1(24-1255) [plasma membrane] (R-HSA-6793976) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449)	0.748	5
UniProt:Q9H5V8 CDCP1			0.734	4
UniProt:P04626 ERBB2	91	p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.708	11
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.702	4
UniProt:P56945 BCAR1	4	p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645) BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723)	0.688	3
UniProt:Q01973 ROR1	2	ROR1 [plasma membrane] (R-HSA-197814) ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727)	0.682	9
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.656	3
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.656	4
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.653	7
UniProt:P55196 AFDN			0.65	7
UniProt:Q14289 PTK2B	3	PTK2B [cytosol] (R-HSA-390932) p-Y-PTK2B [cytosol] (R-HSA-508515) PTK2B [cytosol] (R-HSA-5218721)	0.643	3
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.623	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.621	3
UniProt:P07550 ADRB2	5	ADRB2 [endosome membrane] (R-HSA-6783036) pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) pS-ADRB2 [plasma membrane] (R-HSA-8852158) ADRB2 [plasma membrane] (R-HSA-390647)	0.611	3
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.609	3
UniProt:P35326 SPRR2A	2	SPRR2A [cytosol] (R-HSA-6810863) SPRR2A [cornified envelope] (R-HSA-8934850)	0.602	3
UniProt:Q62884 Q62884			0.602	3
UniProt:P61978 HNRNPK	2	SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.593	6
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.591	13
UniProt:P27635 RPL10	1	RPL10 [cytosol] (R-HSA-72402)	0.591	6
UniProt:P16284 PECAM1	4	PECAM1 [secretory granule membrane] (R-HSA-6804778) PECAM1 [platelet alpha granule membrane] (R-HSA-61489) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [plasma membrane] (R-HSA-114686)	0.59	3
UniProt:P00519 ABL1	5	ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610)	0.589	2
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.573	3
UniProt:P34152 Ptk2	13	phospho-p-Y397-PTK2 [cytosol] (R-MMU-354068) phospho-p-6Y-PTK2 [cytosol] (R-MMU-354128) PTK2 [cytosol] (R-MMU-201621) phospho-p-6Y,S732-PTK2 [cytosol] (R-MMU-5218694) phospho-p-5Y,S732-PTK2 [cytosol] (R-MMU-5229006) phospho-p-5Y-PTK2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) p-Y428-FAK1 [cytosol] (R-MMU-3928397) phospho-p-Y194,Y397-PTK2 [cytosol] (R-MMU-8874600) phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-MMU-8874613) PTK2(1-772) [cytosol] (R-MMU-202827) PTK2(773-1052) [cytosol] (R-MMU-202829) phospho-pY-PTK2 [cytosol] (R-MMU-9632393)	0.564	2
UniProt:P07948 LYN	5	p-Y396-LYN [plasma membrane] (R-HSA-2454229) LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943)	0.564	2
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.564	2
linoleoyl-CoA [ChEBI:15530]	2	LIN-CoA [mitochondrial matrix] (R-ALL-77359) LA-CoA [endoplasmic reticulum lumen] (R-ALL-2046063)	0.558	2
myristoyl-CoA [ChEBI:15532]	3	MYS-CoA [cytosol] (R-ALL-184174) MYS-CoA [cytosol] (R-ALL-2534019) MYS-CoA [mitochondrial matrix] (R-ALL-77272)	0.558	2
UniProt:O43184 ADAM12	1	ADAM12 [plasma membrane] (R-HSA-179792)	0.558	2
UniProt:Q9BR61 ACBD6	1	ACBD6 [cytosol] (R-HSA-8848243)	0.558	4
UniProt:Q8R5G7	1	ARAP3 [cytosol] (R-MMU-195185)	0.558	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	6
UniProt:P97288	1	HTR4 [plasma membrane] (R-MMU-391008)	0.544	2
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.544	2
UniProt:P25962	1	ADRB3 [plasma membrane] (R-MMU-390623)	0.544	2
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) STAT3 [cytosol] (R-HSA-539044)	0.527	5
UniProt:P19367 HK1	4	HK1 L529S [cytosol] (R-HSA-5621861) HK1 [cytosol] (R-HSA-70395) HK1 577-672del [cytosol] (R-HSA-5621873) HK1 T680S [cytosol] (R-HSA-5621880)	0.524	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873)	0.524	2
UniProt:P12814 ACTN1	3	ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [cytosol] (R-HSA-354096) ACTN1 [extracellular region] (R-HSA-349722)	0.524	2
UniProt:P12830 CDH1	10	CDH1(751-882) [plasma membrane] (R-HSA-3827962) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-750) [plasma membrane] (R-HSA-202940)	0.499	2
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.499	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) IKBKG [cytosol] (R-HSA-168108) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397)	0.499	3
ChEBI:39112 BOSUTINIB			0.499	2
ChEBI:45783 IMATINIB			0.499	2
UniProt:O15455 TLR3	6	TLR3 P554S [endosome membrane] (R-HSA-5602428) TLR3 E746* [endosome membrane] (R-HSA-5602730) TLR3 [endoplasmic reticulum membrane] (R-HSA-1679057) TLR3 [endolysosome membrane] (R-HSA-167941) TLR3 [Golgi membrane] (R-HSA-1678955) TLR3 [endosome membrane] (R-HSA-2000341)	0.463	2
UniProt:P23743 DGKA	1	DGKA [plasma membrane] (R-HSA-426056)	0.462	2