GGA3 associates with activated MET receptor

Stable Identifier
R-HSA-8875661
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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GGA3 associates with the activated MET receptor through the CRK adapter and the ARF6:GTP complex and co-localizes with the MET receptor at early endosome membranes. The mechanistic details of GGA3 recruitment to MET have not been elucidated. GGA3 promotes recycling of the activated MET receptor through a RAB4-positive endosomal compartment (Parachoniak et al. 2011).

Literature References
PubMed ID Title Journal Year
21664574 GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration

Parachoniak, CA, Luo, Y, Abella, JV, Keen, JH, Park, M

Dev. Cell 2011
Participants
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Orthologous Events
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Created