Reactome | TMEM86B [endoplasmic reticulum membrane]

TMEM86B [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-8874443

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Lysoplasmalogenase ecNumber3.3.2.2/ecNumber ecNumber3.3.2.5/ecNumber, TM86B_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9P0S9 TM14C

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External Reference Information

External Reference

UniProt:Q8N661 TMEM86B

Gene Names

TMEM86B

Chain

chain:1-226

Reference Genes

BioGPS Gene:255043 TMEM86B

COSMIC (genes):TMEM86B TMEM86B

CTD Gene:255043 TMEM86B

dbSNP Gene:255043 TMEM86B

ENSEMBL:ENSG00000180089 TMEM86B

HGNC:28448 TMEM86B

KEGG Gene (Homo sapiens):255043 TMEM86B

Monarch:255043 TMEM86B

NCBI Gene:255043 TMEM86B

OMIM:617806 TMEM86B

UCSC:Q8N661 TMEM86B

Reference Transcript

RefSeq:NM_173804.4 TMEM86B

Other Identifiers

0006840088

11754415_a_at

16875677

229736_at

255043

3871243

3871244

3871245

3871246

3871247

3871248

3871250

3871253

3871254

3871255

3871257

57689

76852_at

8039409

A_24_P121956

AAH23000

AC010327

BC023000

CCDS12920

ENSG00000180089

ENSP00000321038

ENST00000327042

ENST00000327042.4

EntrezGene:255043

EntrezGene:TMEM86B

GE495160

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005783

GO:0005789

GO:0006629

GO:0008150

GO:0016020

GO:0016021

GO:0016787

GO:0016803

GO:0036151

GO:0043226

GO:0044281

GO:0046485

GO:0047408

GO:0047409

HGNC:28448

HPA057689

Hs.135215.0.A1_3p_at

ILMN_1769107

ILMN_2049417

IPR012506

MIM:617806

NM_173804

NP_776165

PF07947

PH_hs_0008163

TC19001863.hg

TMEM86B

TMEM86B-201

UPI0000141ABB

XM_017026554

XP_016882043

Inferred To

TMEM86B [endoplasmic reticulum membrane] (Bos taurus)

TMEM86B [endoplasmic reticulum membrane] (Caenorhabditis elegans)

TMEM86B [endoplasmic reticulum membrane] (Canis familiaris)

TMEM86B [endoplasmic reticulum membrane] (Danio rerio)

TMEM86B [endoplasmic reticulum membrane] (Dictyostelium discoideum)

TMEM86B [endoplasmic reticulum membrane] (Drosophila melanogaster)

TMEM86B [endoplasmic reticulum membrane] (Gallus gallus)

TMEM86B [endoplasmic reticulum membrane] (Mus musculus)

TMEM86B [endoplasmic reticulum membrane] (Rattus norvegicus)

TMEM86B [endoplasmic reticulum membrane] (Sus scrofa)

Homologues of TMEM86B [endoplasmic reticulum membrane] (Danio rerio)

Cross References

RefSeq

NP_776165.3

OpenTargets

ENSG00000180089

GeneCards

Q8N661

PRO

Q8N661

HMDB Protein

HMDBP11979

Interactors (86)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXK5 B2L13			0.696	5
UniProt:Q96LL9 DJC30			0.488	2
UniProt:O95183 VAMP5			0.488	2
UniProt:Q9H2L4 TMM60			0.488	2
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.488	2
UniProt:B2RUZ4 SMIM1			0.488	2
UniProt:Q15836 VAMP3	6	VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.488	2
UniProt:Q96A25 T106A			0.488	2
UniProt:Q9NS64 RPRM			0.488	2
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920) VAPA [plasma membrane] (R-HSA-6806269) VAPA [azurophil granule membrane] (R-HSA-6799364)	0.488	2
UniProt:Q86Y82 STX12			0.488	2
UniProt:P07307-3 ASGR2			0.488	2
UniProt:P07204 THBD	1	THBD [plasma membrane] (R-HSA-141030)	0.488	2
UniProt:Q9Y680 FKBP7			0.488	2
UniProt:Q969S6 TM203			0.488	2
UniProt:Q8WV19 SFT2A			0.488	2
UniProt:Q5QGT7 RTP2	1	RTP2 [plasma membrane] (R-HSA-8939446)	0.488	2
UniProt:Q9H0Q3 FXYD6	1	FXYD6 [plasma membrane] (R-HSA-2752104)	0.488	2
UniProt:P30040 ERP29			0.488	2
UniProt:Q9H400 LIME1			0.488	2
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.488	2
UniProt:Q6UXN8 CLC9A			0.488	2
UniProt:Q3SXY8 ARL13B	7	PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) ARL13B [cilium] (R-HSA-5618181) Misfolded ARL13B [cilium] (R-HSA-9640116) Misfolded ARL13B [cytosol] (R-HSA-9640110) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986)	0.488	2
UniProt:O14880 MGST3	1	MGST3 [endoplasmic reticulum membrane] (R-HSA-176053)	0.488	2
UniProt:Q5JX71 F209A			0.488	2
UniProt:P26678 PLN	2	PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319) p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813)	0.488	2
UniProt:P19397 CD53	3	CD53 [plasma membrane] (R-HSA-6804817) CD53 [tertiary granule membrane] (R-HSA-6804799) CD53 [specific granule membrane] (R-HSA-6804793)	0.488	2
UniProt:Q8N5I4 DHRSX			0.488	2
UniProt:O14523 C2C2L			0.488	2
UniProt:Q96HA9 PX11C			0.488	2
UniProt:O14925 TIMM23	2	TIMM23 [mitochondrial inner membrane] (R-HSA-1252126) TIMM23 [mitochondrial intermembrane space] (R-HSA-1299436)	0.488	2
UniProt:Q8N6S5 AR6P6			0.488	2
UniProt:Q8TEB9 RHBL4			0.488	2
UniProt:Q96JA4 M4A14			0.488	2
UniProt:Q9Y375 NDUFAF1	1	NDUFAF1 [mitochondrial inner membrane] (R-HSA-5689050)	0.488	2
UniProt:Q9NUM3 S39A9			0.488	2
UniProt:P13236 CCL4	1	CCL4(24-92) [extracellular region] (R-HSA-443976)	0.488	2
UniProt:Q8N474 SFRP1	1	SFRP1 [extracellular region] (R-HSA-2980916)	0.488	2
UniProt:Q96HJ3-2 Q96HJ32			0.488	2
UniProt:Q8TBE7 S35G2			0.488	2
UniProt:Q96FB2 Q96FB2			0.488	2
UniProt:Q53FV1 ORMDL2	1	ORMDL2 [endoplasmic reticulum membrane] (R-HSA-8865591)	0.488	2
UniProt:Q02747 GUCA2A	1	GUCA2A(22-115) [extracellular region] (R-HSA-8936191)	0.488	2
UniProt:Q9P0B6 CC167			0.488	2
UniProt:Q8WY91 THAP4			0.488	2
UniProt:Q9NUU6 OTULL			0.488	2
UniProt:Q9P0N8 MARH2			0.488	2
UniProt:Q9Y6G1 TM14A			0.488	2
UniProt:Q9NWD8 TM248			0.488	2
UniProt:Q9GZY8-5 MFF			0.488	2
UniProt:Q9Y624 F11R	2	F11R [plasma membrane] (R-HSA-197845) F11R [cell junction] (R-HSA-2134498)	0.488	2
UniProt:Q6UX40 TM107			0.488	2
UniProt:A0AVG3 A0AVG3			0.488	2
UniProt:Q9Y5U9 IR3IP			0.488	2
UniProt:Q8WWF3 SSMM1			0.488	2
UniProt:Q9BXJ8 T120A			0.488	2
UniProt:Q9Y282 ERGI3			0.488	2
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.488	2
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.488	2
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.488	2
UniProt:P48449 LSS	1	LSS [endoplasmic reticulum membrane] (R-HSA-191371)	0.488	2
UniProt:O43752 STX6	2	STX6 [Golgi membrane] (R-HSA-6811004) STX6 [trans-Golgi network membrane] (R-HSA-6811007)	0.488	2
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.488	2
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.488	2
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.488	2
UniProt:Q9NZG7 NINJ2			0.488	2
UniProt:Q13323 BIK			0.488	2
UniProt:Q6UX34 SNORC			0.488	2
UniProt:Q8N966 ZDH22			0.488	2
UniProt:O60883 GPR37L1	1	GPR37L1 [plasma membrane] (R-HSA-5336178)	0.488	2
UniProt:Q14210 LY6D	2	GPI-LY6D [plasma membrane] (R-HSA-8940697) cleaved GPI-LY6D [extracellular region] (R-HSA-8941095)	0.488	2
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.488	2
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.488	2
UniProt:Q8TD22 SFXN5			0.488	2
UniProt:O15393-2 TMPRSS2			0.488	2
UniProt:Q96IV6 FXDC2			0.488	2
UniProt:Q9NSU2-1 TREX1			0.488	2
UniProt:O43169 CYB5B	1	CYB5B [mitochondrial outer membrane] (R-HSA-8943390)	0.488	2
UniProt:Q9UNK0 STX8			0.488	2
UniProt:P27105 STOM	4	STOM [azurophil granule membrane] (R-HSA-6800997) STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569)	0.488	2
UniProt:Q96Q45-2 TMEM237			0.488	2
UniProt:Q07326 PIGF	1	PIGF [endoplasmic reticulum membrane] (R-HSA-162819)	0.488	2
UniProt:Q9P0S9 TM14C			0.488	2
UniProt:O95393 BMP10	2	BMP10 [extracellular region] (R-HSA-8858374) BMP10(22-424) [extracellular region] (R-HSA-2396409)	0.488	2
UniProt:Q01628 IFITM3	1	IFITM3 [plasma membrane] (R-HSA-1015688)	0.488	2
UniProt:P17302 GJA1	6	GJA1 [Golgi membrane] (R-HSA-190649) GJA1 [endoplasmic reticulum membrane] (R-HSA-190654) GJA1 [lysosomal membrane] (R-HSA-196173) p-Y265-GJA1 [plasma membrane] (R-HSA-191657) GJA1 [Golgi-associated vesicle membrane] (R-HSA-190544) GJA1 [plasma membrane] (R-HSA-158058)	0.488	2