Reactome | PTK2 autophosphorylates

PTK2 autophosphorylates

Stable Identifier

R-HSA-8874078

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Binding to activated MET promotes PTK2 (FAK1) autophosphorylation at tyrosine residue Y397, a step involved in HGF-triggered cell migration (Chen and Chen 2006). It was demonstrated that PTK2 may associate with activated MET as a homodimer and that autophosphorylation at Y397 of PTK2 may happen in trans (Brami-Cherrier et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24480479	FAK dimerization controls its kinase-dependent functions at focal adhesions Bouceba, T, Gasmi, L, Leonard, PG, Gervasi, N, Walkiewicz, K, Boutterin, MC, Brami-Cherrier, K, Seantier, B, Arsenieva, D, Arold, ST, Ortega, A, Kadaré, G, Girault, JA	EMBO J.	2014
16782899	Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion Chen, HC, Chen, SY	Mol. Cell. Biol.	2006