Phosphorylated FOXO3 translocates to the nucleus

Stable Identifier
R-HSA-8870628
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Phosphorylated FOXO3 translocates to the nucleus
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CDK5-mediated phosphorylation of the transcription factor FOXO3 promotes translocation of FOXO3 from the cytosol to the nucleus (Shi et al. 2016).
Literature References
PubMed ID Title Journal Year
26962010 Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

Viccaro, K, Shi, C, Lee, HG, Shah, K

J. Cell. Sci. 2016
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Alzheimer's disease DOID:10652 AD, Alzheimers dementia, Alzheimer disease
Authored
Shah, K  (2016-02-23)
Created
Orlic-Milacic, M  (2016-05-11)
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