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DERL3 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-8866516
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Derlin-3, DERL3_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective CFTR causes cystic fibrosis (Homo sapiens)
CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 and RNF185 ubiquitinate CFTR F508del (Homo sapiens)
CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Homo sapiens)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL3 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96Q80 DERL3
Gene Names
DERL3, C22orf14, DER3, LLN2
Chain
chain:1-235
Reference Genes
BioGPS Gene:91319 DERL3
COSMIC (genes):DERL3 DERL3
CTD Gene:91319 DERL3
dbSNP Gene:91319 DERL3
ENSEMBL:ENSG00000099958 DERL3
ENSEMBL_homo_sapiens_GENE:ENSG00000099958.15 DERL3
ENSEMBL_homo_sapiens_GENE:ENSG00000274437.4 DERL3
HGNC:14236 DERL3
KEGG Gene (Homo sapiens):91319 DERL3
Monarch:91319 DERL3
NCBI Gene:91319 DERL3
OMIM:610305 DERL3
UCSC:Q96Q80 DERL3
Reference Transcript
RefSeq:NM_198440.3 DERL3
RefSeq:NM_001135751.1 DERL3
RefSeq:XM_011530506.2 DERL3
RefSeq:NM_001002862.2 DERL3
Other Identifiers
11728406_x_at
11728407_a_at
11728408_x_at
11733285_x_at
16933062
228897_PM_at
228897_at
229721_PM_x_at
229721_x_at
3954909
3954911
3954912
3954913
3954914
3954915
3954916
3954917
3954918
3954919
3954920
3954921
3954922
3954925
3954926
3954927
3954928
3954931
3954933
3954935
3954937
3954938
56599_i_at
56602_f_at
80262_at
8074944
91319
A_23_P6362
A_24_P239343
A_33_P3724155
A_33_P3724157
GE62539
GE872830
GO:0000839
GO:0005047
GO:0005515
GO:0005783
GO:0005789
GO:0006486
GO:0006886
GO:0006950
GO:0010498
GO:0016020
GO:0018279
GO:0023052
GO:0030163
GO:0030433
GO:0030968
GO:0036211
GO:0043226
GO:0044877
GO:0051787
GO:1901135
GO:1904153
GO:1990381
HMNXSV003023749
HMNXSV003034765
Hs.14587.0.S1_3p_x_at
Hs.14587.2.A1_3p_a_at
Hs.14587.2.A1_3p_x_at
ILMN_1651415
ILMN_1731111
PH_hs_0031927
TC22000569.hg
Participates
as a candidate of
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
DERL3 [endoplasmic reticulum membrane]
(Bos taurus)
DERL3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
DERL3 [endoplasmic reticulum membrane]
(Canis familiaris)
DERL3 [endoplasmic reticulum membrane]
(Gallus gallus)
DERL3 [endoplasmic reticulum membrane]
(Sus scrofa)
Der-2 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Derl3 [endoplasmic reticulum membrane]
(Mus musculus)
Derl3 [endoplasmic reticulum membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_940842.2
,
XP_011528808.1
,
NP_001129223.1
,
NP_001002862.1
OpenTargets
ENSG00000099958
HPA
ENSG00000099958-DERL3
GeneCards
Q96Q80
Ensembl
ENST00000631305
,
ENSP00000315303
,
ENST00000406855
,
ENSG00000099958
,
ENST00000476077
,
ENST00000620697
,
ENST00000318109
,
ENSP00000384744
,
ENSP00000485763
,
ENST00000628868
,
ENSP00000483693
,
ENSP00000486587
,
ENSG00000274437
,
ENSP00000419399
PRO
Q96Q80
Pharos - Targets
Q96Q80
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22749 GNLY
2
GNLY [phagocytic vesicle lumen]
(R-HSA-6807564)
GNLY [extracellular region]
(R-HSA-6806691)
0.556
3
UniProt:Q05329 GAD2
2
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888582)
PXLP-K396-GAD2 [plasma membrane]
(R-HSA-936509)
0.556
3
UniProt:Q6UWB1 IL27RA
4
sIL27RA [cytoplasm]
(R-HSA-8950653)
sIL27RA [extracellular region]
(R-HSA-8950454)
p-Y611-IL27RA [plasma membrane]
(R-HSA-8950330)
IL27RA [plasma membrane]
(R-HSA-448478)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q08426 EHHADH
2
EHHADH [peroxisomal matrix]
(R-HSA-400155)
EHHADH [cytosol]
(R-HSA-9033147)
0.556
3
UniProt:Q9UKG4 SLC13A4
1
SLC13A4 [plasma membrane]
(R-HSA-433098)
0.556
3
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