TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression

Stable Identifier
R-HSA-8864466
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression
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Binding of AP-2 transcription factors TFAP2A (AP-2 alpha), TFAP2B (AP-2 beta) and TFAP2C (AP-2 gamma) to AP-2 response elements in the ERBB2 gene promoter stimulates ERBB2 transcription, with TFAP2B having the weakest effect (Bosher et al. 1996). Association of YY1 transcription factor with TFAP2A (and, possibly, TFAP2B and TFAP2C) significantly increases the ERBB2 gene transcription rate (Begon et al. 2005).
Literature References
PubMed ID Title Journal Year
15870067 Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells

Jackers, P, Vernimmen, D, Begon, DY, Winkler, R, Delacroix, L

J. Biol. Chem. 2005
8895516 A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma

Williams, T, Totty, NF, Bosher, JM, Hsuan, JJ, Hurst, HC

Oncogene 1996
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This event is regulated
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Regulator
TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers:YY1:ERBB2 gene [nucleoplasm] (Homo sapiens)
Active Unit
TFAP2A,(TFAP2B,TFAP2C) dimers:YY1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Dawid, IB  (2016-05-04)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-03-16)
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