TPX2 binding to Aurora A protects premature AURKA degradation by APC/C-mediated proteolysis during early mitosis. TPX2 differentially regulates AURKA stability, activity and localization. While amino acids 1-43 in TPX2 facilitate complex formation between AURKA and TPX2 and promote kinase activation, they are insufficient for AURKA targeting to the mitotic spindle (Giubettini et al. 2011).
Groen, AC, Coughlin, M, Ohi, R, Mitchison, TJ, Cameron, LA, Miyamoto, DT
Belch, AR, Pilarski, LM, Reiman, T, Keats, JJ, Maxwell, CA
Sardon, T, Scrofani, J, Vernos, I, Meunier, S
Sardon, T, Bayliss, R, Conti, E, Vernos, I
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