PTK6 phosphorylates PXN

Stable Identifier
R-HSA-8848606
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated PTK6 (BRK) phosphorylates PXN (paxillin) on tyrosine residues Y31 and Y118. PTK6-mediated phosphorylation of PXN can be triggered by EGF stimulation (Chen et al. 2004).

Literature References
PubMed ID Title Journal Year
15572663 Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

Chen, HY, Shen, CH, Tsai, YT, Lin, FC, Huang, YP, Chen, RH

Mol. Cell. Biol. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-Y342-PTK6:PXN [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created