Reactome | PTEN binds FRK

PTEN binds FRK

Stable Identifier

R-HSA-8847968

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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FRK (RAK), a SRC family member kinase, binds PTEN. The interaction involves the SH3 domain of FRK and the C2 domain of PTEN (Yim et al. 2009). Like other SRC family members, FRK is autophosphorylated on a C-terminal tyrosine residue Y387. FRK possesses a nuclear localization signal and is found in both nucleus and the cytosol (Cance et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
19345329	Rak functions as a tumor suppressor by regulating PTEN protein stability and function Li, K, Dai, H, Lu, Y, Hu, R, Craven, RJ, Hennessy, BT, Meric-Bernstam, F, Mills, GB, Yim, EK, Lin, SY, Peng, G	Cancer Cell	2009