Reactome | Synthesis of PIPs in the nucleus

Synthesis of PIPs in the nucleus

Stable Identifier

R-HSA-8847453

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Under conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase. Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase TMEM55B translocates to the nucleus under stress via an unknown mechanism (Zou et al. 2007) and generates PI5P from the PI(4,5)P2 substrate. The level of PI5P in the nucleus is kept low because of the phosphatidylinositol-5-phosphate 4-kinase activity of nuclear PIP4K2 dimers, mainly dimers containing PIP4K2B (Ciruela et al. 2000). Under conditions of cellular stress, nuclear PIP4K2B is phosphorylated and inactivated by p38 MAP family kinases (Jones et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16949365	Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta Jones, DR, D'Santos, CS, Bultsma, Y, Heck, AJ, Keune, WJ, Halstead, JR, Divecha, N, Mohammed, S, Elouarrat, D	Mol. Cell	2006
17940011	Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis Marjanovic, J, Majerus, PW, Kisseleva, MV, Wilson, M, Zou, J	Proc. Natl. Acad. Sci. U.S.A.	2007
10698683	Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7 Ciruela, A, Irvine, RF, Hinchliffe, KA, Divecha, N	Biochem. J.	2000