Reactome | IFNAR1 [plasma membrane]

IFNAR1 [plasma membrane]

Stable Identifier

R-HSA-877334

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interferon alpha/beta receptor 1, INAR1_HUMAN

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External Reference Information

External Reference

UniProt:P17181 IFNAR1

Gene Names

IFNAR1, IFNAR

Chain

signal peptide:1-27, chain:28-557

Reference Genes

BioGPS Gene:3454 IFNAR1

COSMIC (genes):IFNAR1 IFNAR1

CTD Gene:3454 IFNAR1

dbSNP Gene:3454 IFNAR1

ENSEMBL:ENSG00000142166 IFNAR1

ENSEMBL_homo_sapiens_GENE:ENSG00000142166.15 IFNAR1

HGNC:5432 IFNAR1

KEGG Gene (Homo sapiens):3454 IFNAR1

Monarch:3454 IFNAR1

NCBI Gene:3454 IFNAR1

OMIM:107450 IFNAR1

UCSC:P17181 IFNAR1

Reference Transcript

Other Identifiers

1157_s_at

11723423_x_at

11723424_at

11723425_at

11748615_a_at

16922260

204191_PM_at

204191_at

225661_PM_at

225661_at

225669_PM_at

225669_at

3454

3918575

3918576

3918582

3918583

3918584

3918585

3918586

3918588

3918590

3918592

3918595

3918597

3918599

3918600

3918601

3918602

3918603

3918604

3918605

3918606

3918607

3918608

3918609

48583_at

8068266

A_33_P3277988

GE57477

GE86827

GO:0002376

GO:0004904

GO:0004905

GO:0005515

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0005886

GO:0006091

GO:0007259

GO:0008269

GO:0009615

GO:0016020

GO:0019221

GO:0019955

GO:0019962

GO:0023052

GO:0031410

GO:0032496

GO:0035457

GO:0035458

GO:0043226

GO:0046425

GO:0060089

GO:0060090

GO:0060337

GO:0098542

GO:0098586

GO:1901857

HMNXSV003051822

Hs.181315.0.A1_3p_at

Hs.181315.0.A2_3p_at

ILMN_1752923

J03171_at

PH_hs_0008658

PH_hs_0022865

TC21000128.hg

g10835182_3p_at

Participates

as a component of

Other forms of this molecule

p-Y466,Y481-IFNAR1 [plasma membrane]

Inferred To

ifngr2.2 [plasma membrane] (Xenopus tropicalis)

il10rb [plasma membrane] (Xenopus tropicalis)

Ifnar1 [plasma membrane] (Mus musculus)

Ifnar1 [plasma membrane] (Rattus norvegicus)

Homologues of IFNAR1 [plasma membrane] (Xenopus tropicalis)

IFNAR1 [plasma membrane] (Bos taurus)

IFNAR1 [plasma membrane] (Canis familiaris)

IFNAR1 [plasma membrane] (Gallus gallus)

IFNAR1 [plasma membrane] (Sus scrofa)

ifngr2.1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_005261021.1, NP_000620.2

Guide to Pharmacology - Targets

1723

OpenTargets

ENSG00000142166

ZINC - Substances

INAR1_HUMAN

ZINC target

P17181

PRO

P17181

PDB

3SE3, 3SE4, 3S98, 4PO6

GeneCards

P17181

HPA

ENSG00000142166-IFNAR1

Ensembl

ENST00000703556, ENSG00000142166, ENST00000270139, ENST00000652450, ENSP00000270139, ENSP00000498654, ENSP00000515348, ENSP00000514785, ENST00000700080, ENST00000703515, ENSP00000515372

Pharos - Targets

P17181

ZINC - Predictions - Purchasable

INAR1_HUMAN

Orphanet

29639

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.758	5
UniProt:P42224 STAT1	8	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.499	2