Reactome | PIAS1 [nucleoplasm]

PIAS1 [nucleoplasm]

Stable Identifier

R-HSA-877307

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 SUMO-protein ligase PIAS1, PIAS1_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        PIAS1,3 [nucleoplasm] (Homo sapiens)
        
        PIAS1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75925 PIAS1

Gene Names

PIAS1, DDXBP1

Chain

initiator methionine:1, chain:2-651

Reference Genes

BioGPS Gene:8554 PIAS1

COSMIC (genes):PIAS1 PIAS1

CTD Gene:8554 PIAS1

dbSNP Gene:8554 PIAS1

ENSEMBL:ENSG00000033800 PIAS1

HGNC:2752 PIAS1

KEGG Gene (Homo sapiens):8554 PIAS1

Monarch:8554 PIAS1

NCBI Gene:8554 PIAS1

OMIM:603566 PIAS1

UCSC:O75925 PIAS1

Reference Transcript

Other Identifiers

0002320138

11737768_a_at

12304

16802389

1V66

216143_at

217862_at

217863_at

217864_s_at

242278_at

3599330

3599331

3599333

3599341

3599366

3599367

3599370

3599372

3599376

3599384

3599388

3599389

3599390

3599392

3599393

3599395

3599400

3599401

3599402

3599403

3599404

3599405

3599406

3599407

3599408

3599409

3599410

3599411

3599412

36573_at

46559_at

55478_at

5743

58682_at

7984453

8554

A_14_P115397

A_23_P163347

A_23_P163353

A_32_P142195

AAB58488

AAC36702

AAD49722

AAI18588

AAI21798

AC107871

AC135628

ACR77525

AF077951

AF167160

AK094641

AK314515

BAG37114

BAG52901

BC118587

BC121797

CAB012304

CCDS45290

CCDS81902

ENSG00000033800

ENSP00000249636

ENSP00000438574

ENST00000249636

ENST00000249636.10

ENST00000545237

ENST00000545237.1

EntrezGene:8554

EntrezGene:PIAS1

FJ997900

g7706636_3p_a_at

GE58693

GO:0000003

GO:0000082

GO:0000122

GO:0000278

GO:0001085

GO:0002376

GO:0003674

GO:0003677

GO:0003712

GO:0003713

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0006357

GO:0006464

GO:0006950

GO:0007049

GO:0007165

GO:0007259

GO:0007283

GO:0008022

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0008283

GO:0008542

GO:0009056

GO:0009058

GO:0016605

GO:0016607

GO:0016740

GO:0016925

GO:0019789

GO:0019899

GO:0019904

GO:0022607

GO:0030154

GO:0030521

GO:0031625

GO:0032436

GO:0033235

GO:0034641

GO:0042127

GO:0043066

GO:0043167

GO:0043226

GO:0045444

GO:0045893

GO:0046872

GO:0048856

GO:0050681

GO:0050877

GO:0051152

GO:0060334

GO:0061665

GO:0065003

GO:0065004

H3BSI8

H3BUL7

HGNC:2752

HPA005743

Hs.250861.0.A1_3p_at

Hs.306457.0.A1_3p_at

Hs.75251.0.S2_3p_at

Hs.75251.0.S3_3p_at

ILMN_1780598

IPR003034

IPR004181

IPR013083

IPR023321

IPR036361

IPR038654

MIM:603566

NM_001320687

NM_016166

NP_001307616

NP_057250

PF02891

PF14324

PH_hs_0004297

PH_hs_0031316

PIAS1

PIAS1-201

PIAS1-202

SM00513

TC15000627.hg

U78524

U78524_at

UPI0000131A8C

UPI0000140A60

XM_011522126

XM_011522127

XM_017022688

XM_017022689

XM_017022690

XM_017022691

XM_024450094

XP_011520428

XP_011520429

XP_016878177

XP_016878178

XP_016878179

XP_016878180

XP_024305862

Participant Of

hasMember

hasComponent

p-STAT1 dimer:PIAS:SUMO1 [nucleoplasm]

input

PIAS1 binds p-STAT1 dimer

hasCandidate

PIAS1,3 [nucleoplasm]

Inferred To

PIAS1 [nucleoplasm] (Bos taurus)

PIAS1 [nucleoplasm] (Caenorhabditis elegans)

PIAS1 [nucleoplasm] (Canis familiaris)

PIAS1 [nucleoplasm] (Danio rerio)

PIAS1 [nucleoplasm] (Dictyostelium discoideum)

PIAS1 [nucleoplasm] (Drosophila melanogaster)

PIAS1 [nucleoplasm] (Gallus gallus)

PIAS1 [nucleoplasm] (Saccharomyces cerevisiae)

PIAS1 [nucleoplasm] (Schizosaccharomyces pombe)

PIAS1 [nucleoplasm] (Sus scrofa)

PIAS1 [nucleoplasm] (Xenopus tropicalis)

Pias1 [nucleoplasm] (Mus musculus)

Pias1 [nucleoplasm] (Rattus norvegicus)

Homologues of PIAS1 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001307616.1, XP_016878177.1, NP_057250.1

OpenTargets

ENSG00000033800

GeneCards

O75925

PRO

O75925

PDB

1V66

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.609	4
UniProt:Q9UIS9 MBD1	2	MBD1 [nucleoplasm] (R-HSA-417134) SUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331)	0.581	3
UniProt:Q13485 SMAD4	18	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R361C [cytosol] (R-HSA-3310983)	0.553	2
UniProt:O75626 PRDM1	1	PRDM1 [nucleoplasm] (R-HSA-6804199)	0.524	2
UniProt:Q9UKL3 CASP8AP2	2	CASP8AP2 [nucleoplasm] (R-HSA-3927945) SUMO1-K1813-CASP8AP2 [nucleoplasm] (R-HSA-3927850)	0.508	4
UniProt:G2XKQ0 SUMO5			0.488	2
UniProt:P03118 VE2			0.488	2